白金妇安颗粒中挥发油β-环状精包合物制备工艺

目的: 优选白金妇安颗粒中挥发油β-环状精包合物制备工艺。方法: 以不同时间挥发油的提取量为指标,采用正交试验法对白金妇安颗粒中的当归、川芎、郁金、牡丹皮的挥发油提取工艺进行优选;以倍他环糊精(β-CD)包封挥发油的包封率为指标,采用正交试验法对白金妇安颗粒中的的挥发油包合工艺进行优选。结果: 药材当归、川芎、郁金、牡丹皮粉碎成粗粉,加5倍量的水,浸泡2 h,水蒸气蒸馏法提取挥发油5 h。取挥发油5倍量的β-环糊精,加入1倍β-CD量20%乙醇,研磨成糊状,加入挥发油,继续研磨2 h,得糊状物,低温干燥。结论: 确定的工艺合理,有效成分提取率高。

Preparation Technology of β-Cyclodextrin Inclusion Compound for Volatile Oil from Baijin Fuan Particle

Objective:To optimize preparation technology of β-cyclodextrin(β-CD) inclusion compound for volatile oil from Baijin Fuan particle. Method:With extraction volume of volatile oil in different time as indexes,orthogonal design was used to optimize extraction processes of volatile oil from Baijin Fuan particle which including Angelica sinensis,Ligusticum chuanxiong,Curcuma longa,Paeonia suffruticosa. With encapsulation efficiency of β-CD encapsulated volatile oil as index,orthogonal design was used to optimize volatile oil inclusion process of Baijin Fuan particle. Result: A. sinensis,L. chuanxiong,C. longa,P. Suffruticosa were crushed into meal, added 5 times the amount of water, soaked 2 hours and extracted 5 h by steam distillation.Took β-CD 5 times the amount of volatile oil, added 1 time the amount of 20% ethanol, ground into paste, added volatile oil, continued to grind 2 hours, low-temperature drying. Conclusion:This optimized process was rational and with high yield of active constituents.