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红花提取物对高脂血症模型大鼠降血脂作用和安全性实验研究
引用本文:杨庆,梁日欣,叶锦霞,王岚,杨滨,付梅红,黄璐琦.红花提取物对高脂血症模型大鼠降血脂作用和安全性实验研究[J].中国实验方剂学杂志,2007,13(11):30-33.
作者姓名:杨庆  梁日欣  叶锦霞  王岚  杨滨  付梅红  黄璐琦
作者单位:中国中医科学院中药研究所,北京,100700
基金项目:科技部科研院所社会公益研究专项(2004DIB2J-062)
摘    要:目的:采用大鼠高脂血症模型观察红花提取物降血脂作用,并进行安全性评价。方法:采用高脂饲料喂养大鼠造成高脂血症模型,口服给药1个月后,腹主动脉采血,测定血清甘油三酯(TG),总胆固醇(TC),低密度脂蛋白胆固醇(LDL-C),高密度脂蛋白胆固醇(HDL-C);小鼠急性毒性实验和大鼠30 d喂养实验。结果:红花水提物明显降低高脂血症大鼠TC,TG,LDL-C;对小鼠最大耐受量大于106.7g生药/kg。大鼠30 d喂养实验,动物无一死亡,无明显中毒症状,各项观察指标不随剂量的增大和受试时间的延长出现剂量反应关系。结论:红花提取物对高脂血症大鼠具有辅助降血脂功能,且无明显的毒性作用。

关 键 词:红花  血脂  安全性试验
文章编号:1005-9903(2007)11-0030-04
收稿时间:2007-04-04
修稿时间:2007年4月4日

Experimental Study on Function of Decreasing Blood-Lipid in Hyperlipidemia Rats and Safety by Extract of Flos Carthami
YANG Qing,LIANG Ri-xin,YE Jin-xi,WANG Lan,YANG Bin,FU Mei-hong,HUANG Lu-qi.Experimental Study on Function of Decreasing Blood-Lipid in Hyperlipidemia Rats and Safety by Extract of Flos Carthami[J].China Journal of Experimental Traditional Medical Formulae,2007,13(11):30-33.
Authors:YANG Qing  LIANG Ri-xin  YE Jin-xi  WANG Lan  YANG Bin  FU Mei-hong  HUANG Lu-qi
Institution:Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China
Abstract:Objective:To observe the function of decreasing blood-lipid by extract from Flos carthami in rat with hyperlipidemia and safety of water extract.Methods:Using hyperlipidemia animal model replicated by hyperlipidemia forage,the levels of TC,TG,HDL,LDL were assayed;actue toxicity test and thirty days feeding study were employed.Results:The levels of TG,TC,LDL-C in all groups treated with the water extract of Flos Carthami were significantly reduced.The alcohol extract of Flos carthami showed a decreased action for TC.For safety,water extract showed no death nor toxic symptom.All the observed index showed no relationship between postponing time and increasing doses during 30 d feeding period.And in teratogenicity tests,pregnant rats grew well;fetuses developed naturally,and the ratio of abnormal fetues was in the range of natural abnormal ratio.Conclusions:The extract of Flos carthami indicaterd the function of decreasing the blood-lipid,and no obvious toxic effects have been observed.
Keywords:Flos Carthami  lipid  safety
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