保济丸粉对小鼠腹泻及肠运动的影响

目的:观察保济丸粉辐照前后对小鼠的腹泻及肠运动的影响.方法:采用蓖麻油致小鼠腹泻模型,观察辐射前后保济丸粉的止泻作用；采用溴吡斯的明致小鼠肠运动亢进模型观察对炭末推进的影响,观察对小鼠不同肠段水分吸收的影响.以上实验辐照前后保济丸粉剂量均为给生药1.3,2.6,5.2 g·kg-1,ig,连续3d.结果:保济丸粉辐照前后可显著延长蓖麻油致小鼠腹泻的起始时间(开始排湿粪时间),显著减少腹泻次数(排泄湿粪次数),与模型对照组比较,P＜0.01；可显著抑制溴吡斯的明所致小鼠小肠运动亢进作用,与模型对照组比较,P ＜0.01或P＜0.05；可显著减少小鼠大肠与小肠水分含量,与正常对照组比较,P＜0.01或P＜0.05.结论:保济丸粉辐照前后均可止泻和抑制肠运动,其止泻作用可能是通过抑制肠运动及减少小鼠肠腔内水分所致.保济丸粉辐照前后的作用比较,差异无显著性.

Effect of Baoji Wan Powder on Diarrhea and Bowel Movement in Mice

Objective:To observe effect of Baoji Wan powder on diarrhea and intestinal motility induced by irradiation in mice.Method:Using castor oil induced diarrhea model,we observed Baoji Wan powder’s(before and after irradiation) antidiarrheal effect at doses of 1.3,2.6,5.2 g·kg-1ig for 3 d in mice.Using pyridostigmine bromide induced hyperthyroidism intestine movement in mice,the effect of Baoji Wan powder on intestine movements was observed.Result:Baoji Wan powder before and after irradiation could significantly extend the castor oil-induced small diarrhea,the starting time of diarrbea(indicated by watery feces),the number of diarrhea,compared with the control group(P<0.01).The powder could significantly inhibit pyridostigmine bromide-induced intestinal motility compared with that in the model group(P<0.01,P<0.05);and it could significantly reduce the water content in colon and small intestine,compared with that in normal control group(P<0.01,P<0.05).Conclusion:Baoji Wan powder before and after irradiation has the effect of inhibiton of diarrhea and suppression of bowel movement,the antidiarrheal effect may be gained by inhibition of bowel movements and reduce of water in intestine.Before and after irradiation,Baoji Wan powder’s difference in effects was not significant.