| 木蹄复方提取物体内抗肿瘤作用研究 |
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| 引用本文： | 何晓义,葛卫红,刘琼,沈先荣,何颖,蒋定文,陈伟,莫琳芳,刘玉明,侯登勇,王庆蓉,钱甜甜. 木蹄复方提取物体内抗肿瘤作用研究[J]. 中国实验方剂学杂志, 2013, 19(15): 170-173 |
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| 作者姓名： | 何晓义 葛卫红 刘琼 沈先荣 何颖 蒋定文 陈伟 莫琳芳 刘玉明 侯登勇 王庆蓉 钱甜甜 |
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| 作者单位： | 1. 浙江中医药大学中药体外代谢实验室,杭州,310053
2. 海军医学研究所防护医学研究室,上海,200433 |
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| 基金项目： | 全军医学科技"十二五"重大项目(AS11J003) |
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| 摘 要： | 目的:考察木蹄复方提取物(ECF)的体内抗肿瘤活性,并探讨部分作用机制.方法:制备S 180和Lewis肺癌实体瘤小鼠模型,接种次日将2种实体瘤模型小鼠均分为模型组,EFC低、中、高剂量(0.05,0.1,0.15 g·kg-1)组和环磷酰胺(CTX)阳性对照组,分别连续给药8和15 d,观察ECF对荷瘤小鼠瘤质量、胸腺指数和脾脏指数、血清中肿瘤坏死因子-α(TNF-α)和巨噬细胞集落刺激因子(M-CSF)水平的影响.结果:ECF低、中、高3个剂量组对S 180荷瘤小鼠肿瘤抑制率分别为11.8％,47.1％和58.8％;对Lewis肺癌实体瘤小鼠肿瘤抑制率分别为7.1％,57.1％和28.6％.与模型组比较,ECF高剂量组能抑制S180荷瘤小鼠肿瘤的生长(P＜0.05),提高胸腺指数(P＜0.05),降低血清中M-CSF水平;中剂量组可抑制Lewis 肺癌荷瘤小鼠肿瘤的生长(P＜0.05),提高胸腺指数(P＜0.05),降低血清中M-CSF水平,3个剂量组均能提高血清中TNF-α水平(P ＜0.05,P＜0.01).结论:ECF对S 180荷瘤小鼠和Lewis肺癌荷瘤小鼠肿瘤的生长具有明显抑制作用,显示较强的体内抗肿瘤活性,其作用机制可能与提高免疫器官指数以及调节血清中TNF-α和M-CSF的表达有关.
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| 关 键 词： | 木蹄复方 体内 抗肿瘤 肿瘤坏死因子-a 巨噬细胞集落刺激因子 |
| 收稿时间： | 2013-01-04 |
Antitumor Effect of Extracts from Compound Fomes fomentarius in vivo |
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| HE Xiao-yi,GE Wei-hong,LIU Qiong,SHEN Xian-rong,HE Ying,JIANG Ding-wen,CHEN Wei,MO Lin-fang,LIU Yu-ming,HOU Deng-yong,WANG Qing-rong and QIAN Tian-tian. Antitumor Effect of Extracts from Compound Fomes fomentarius in vivo[J]. China Journal of Experimental Traditional Medical Formulae, 2013, 19(15): 170-173 |
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| Authors: | HE Xiao-yi GE Wei-hong LIU Qiong SHEN Xian-rong HE Ying JIANG Ding-wen CHEN Wei MO Lin-fang LIU Yu-ming HOU Deng-yong WANG Qing-rong QIAN Tian-tian |
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| Affiliation: | Metabolism Laboratory of Traditional Chinese Medicine(TCM), Zhejiang Chinese Medicine University, Hangzhou 310053, China;Metabolism Laboratory of Traditional Chinese Medicine(TCM), Zhejiang Chinese Medicine University, Hangzhou 310053, China;Department of Radiation Protection Medicine, Navy Medical Research Institute, Shanghai 200433, China;Department of Radiation Protection Medicine, Navy Medical Research Institute, Shanghai 200433, China;Department of Radiation Protection Medicine, Navy Medical Research Institute, Shanghai 200433, China;Department of Radiation Protection Medicine, Navy Medical Research Institute, Shanghai 200433, China;Department of Radiation Protection Medicine, Navy Medical Research Institute, Shanghai 200433, China;Department of Radiation Protection Medicine, Navy Medical Research Institute, Shanghai 200433, China;Department of Radiation Protection Medicine, Navy Medical Research Institute, Shanghai 200433, China;Department of Radiation Protection Medicine, Navy Medical Research Institute, Shanghai 200433, China;Department of Radiation Protection Medicine, Navy Medical Research Institute, Shanghai 200433, China;Department of Radiation Protection Medicine, Navy Medical Research Institute, Shanghai 200433, China |
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| Abstract: | |
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| Keywords: | compound Fomes fomentarius in vivo antitumor TNF-α M-CSF |
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