醒脑静乳剂对家兔失血性休克及感染性休克的保护作用

目的 :观察醒脑静乳剂对家兔失血性休克及感染性休克的保护作用。 方法 :通过股动脉放血制造家兔失血性休克模型,耳缘静脉注射大肠杆菌内毒素制造家兔感染性休克模型。造模成功家兔分别随机分成5组,每组8只,为模型对照组及醒脑静乳剂(102.75,51.4,25.7 mg·kg^-1)3个剂量组及阳性药对照(醒脑静注射液,51.4 mg·kg^-1)组,观察醒脑静乳剂的抗休克作用。 结果: 醒脑静乳剂可显著升高血压,减少血浆中丙二醛(MDA)形成,提高超氧化物歧化酶(SOD)活性;升高失血性休克家兔的心率;并可延长感染性休克家兔的存活时间,降低其死亡率和一氧化氮(NO)水平。 结论 :醒脑静乳剂对家兔失血性休克及感染性休克具有保护作用,可能是通过改善微循环、抗脂质过氧化等达到抗休克目的。

Protective Effect of Xingnaojing Emulsion on Hemorrhagic Shock and Septic Shock in Rabbits

Objective: To observe the protective effect of Xingnaojing Emulsion (XNJE) on hemorrhagic shock and septic shock in rabbits. Methods: A rabbit model of hemorrhagic shock was established by bloodletting from femoral artery of rabbits; LPS of E.coli was injected to rabbits via vein to induce septic shock. The successful model rabbits were equally and randomly assigned into 5 groups: normal saline (NS) control group, low, middle and high dose of XNJE (25.7,51.4,102.75 mg·kg^-1)group and positive control group (treated with Xingnaojing injection, 51.4 mg·kg^-1) (n=8 for each group). The antishock effect of XNJE was then observed. Results: In the hemorrhagic shock model, XNJE could obviously heighten the blood pressure, quicken the heart rate, inhibit the abnormal increase of MDA and enhance the activity of SOD in serum.Besides, in the septic shock model, XNJE could lower the death rate of rabbits, extend the survival time, heighten the blood pressure, inhibit the abnormal increase of MDA, lower the content of NO and enhance the activity of SOD in serum. Conclusion: XNJE exerts a protective effect on hemorrhagic shock and septic shock in rabbits, which could be related with the improvement of microcirculation and antioxidation.