祛瘀化痰汤对多囊卵巢综合征患者卵巢多囊样改变、内分泌及代谢的影响

目的:探讨祛瘀化痰汤对多囊卵巢综合征患者卵巢多囊样改变、内分泌及代谢的影响,并探讨其作用机制。方法:选取新乡医学院第一附属医院妇产科符合纳入标准的92例多囊卵巢综合征患者,按随机数字表法分为对照组和观察组,各46例,对照组予以炔雌醇环丙孕酮,1片/d,观察组在常规治疗基础上联用祛瘀化痰汤治疗,共治疗3个月经周期,测定血清学指标,记录卵巢多囊样改变,同时对比临床疗效。结果:与治疗前比较,两组患者治疗后促卵泡生成素(FSH),黄体生成素(LH)和睾酮(T)含量降低,雌二醇(E_2)含量升高,糖脂代谢指标降低,内脂素(VF),瘦素(LEP)含量降低,脂联素(APN)含量升高,卵巢体积和卵巢内卵泡数量明显降低(P0.05);与对照组比较,观察组治疗后FSH,LH和T含量较低,E_2含量较高,糖脂代谢指标较低,VF,LEP含量较低,APN含量较高,卵巢体积和卵巢内卵泡数量明显降低(P0.05);对照组有效率(73.91%)明显低于观察组(91.31%)(P0.05)。结论:祛瘀化痰汤治疗多囊卵巢综合征疗效确切,可改善卵巢多囊样改变、内分泌及代谢功能。

Effect of Quyu Huatan Decoction on Polycystic Change, Endocrine and Metabolism in Patients with Polycystic Ovary Syndrome

Objective: To investigate the effect of Quyu Huatan decoction on ovary polycystic change, endocrine and metabolism in patients with polycystic ovary syndrome, and explore its action mechanism. Method: The 92 patients who met the inclusion criteria in the department of endocrinology in our hospital were selected and randomly divided into 2 group, 46 cases in control group and 46 cases in observation group. Patients in control group were treated with ethinylestradiol and cyproterone acetate, 1 tablet a day, and patients in treatment group received Quyu Huatan decoction based on the treatment in control group. All patients were treated for 3 menstrual cycles, and then their serological index, polycystic ovarian changes, and clinical efficacy were compared after the treatment. Result: After treatment, the levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH) and testosterone (T) were decreased, levels of estradiol (E₂) were increased, levels of glucose and lipid metabolism indexes were decreased; levels of visfatin (VF), leptin (LEP) were decreased,levels of adiponectin (APN) were increased, and the number of ovarian follicles and ovarian volume were decreased in both groups (P<0.05). As compared with control group, levels of FSH, LH and T were lower, levels of E₂ were higher, levels of glucose and lipid metabolism indexes were lower, levels of VF, LEP were lower, levels of APN were higher, and the number of ovarian follicles and ovarian volume were lower in treatment group after treatment (P<0.05). The effective rate in control group (73.91%) was significantly lower than that in observation group (91.31%) (P<0.05). Conclusion: Quyu Huatan decoction had clear clinical efficacy in the treatment of polycystic ovary syndrome, and it can improve ovary polycystic changes, endocrine and metabolic function.