| 葛根素微乳凝胶的制备及体外释放考察 |
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| 引用本文： | 蒋楠,孙雯,李晔,李彤晖,辛永洁.葛根素微乳凝胶的制备及体外释放考察[J].中国实验方剂学杂志,2012,18(21):34-36. |
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| 作者姓名： | 蒋楠 孙雯 李晔 李彤晖 辛永洁 |
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| 作者单位： | 1. 陕西中医学院,陕西咸阳,712046
2. 陕西省中医药研究院,西安,710003 |
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| 基金项目： | 2009年陕西省科技发展计划项目(2009K19-03) |
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| 摘 要： | 目的:制备葛根素微乳凝胶并考察其体外释放度。方法:采用Franz扩散池对葛根素微乳凝胶进行体外释放试验研究。结果:葛根素微乳凝胶在5 h内释放较快,6～24 h释放稳定。体外释放度经一级、零级和Higuchi方程3种常用的数学模型拟合,结果葛根素微乳凝胶的体外释药符合Higuchi释放模型。结论:葛根素微乳凝胶体外释放性能良好,有一定的缓释作用。
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| 关 键 词： | 葛根素 微乳凝胶 体外释放度 |
| 收稿时间： | 2012/6/26 0:00:00 |
Preparation and in vitro Release Investigation of Puerarin Microemulsion Gel |
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| JIANG Nan,SUN Wen,LI Ye,LI Tong-hui and XIN Yong-jie.Preparation and in vitro Release Investigation of Puerarin Microemulsion Gel[J].China Journal of Experimental Traditional Medical Formulae,2012,18(21):34-36. |
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| Authors: | JIANG Nan SUN Wen LI Ye LI Tong-hui and XIN Yong-jie |
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| Institution: | Shaanxi University of Chinese Medicine, Xianyang 712046, China;Shaanxi University of Chinese Medicine, Xianyang 712046, China;Shaanxi Province Chinese Medicine Research Institute, Xi'an 710003, China;Shaanxi Province Chinese Medicine Research Institute, Xi'an 710003, China;Shaanxi Province Chinese Medicine Research Institute, Xi'an 710003, China |
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| Abstract: | Objective: To prepare puerarin microemulsion gel,and to investigate its in vitro release. Method: In vitro release test of puerarin microemulsion gel was studied by modified Franz diffusion cell. Result: Puerarin microemulsion gel released quickly in 5 h,but it stable release within 6-24 h.Through the first-order equation, zero-order equation and Higuchi equation of 3 kinds of common mathematical model fitting,it showed that in vitro release of puerarin microemulsion gel conformed to Higuchi release model. Conclusion: Puerarin microemulsion gel had a good property of in vitro release,and had a certain sustained release effect. |
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| Keywords: | puerarin microemulsions gel in vitro release |
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