| 均匀设计优选维药行气那尼花颗粒挥发油的β-环糊精包合工艺 |
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| 引用本文： | 南京,刘承,叶晓川,刘焱文.均匀设计优选维药行气那尼花颗粒挥发油的β-环糊精包合工艺[J].中国实验方剂学杂志,2013,19(13):53-56. |
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| 作者姓名： | 南京 刘承 叶晓川 刘焱文 |
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| 作者单位： | 1. 湖北中医药大学药学院,武汉,430065
2. 湖北中医药大学药学院,武汉430065;湖北省中药资源与中药化学重点实验室,武汉430065 |
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| 摘 要： | 目的:优化行气那尼花颗粒中挥发油的β-环糊精(β-CD)包合工艺.方法:采用饱和水溶液法制备行气那尼花颗粒挥发油β-CD包合物.以挥发油包合率和包合物收得率为综合评价指标,采用均匀试验考察挥发油与β-CD的比例、包合温度、包合时间对包合工艺的影响.应用XRD,DSC,IR,UV及TLC对制备的包合物进行表征.结果:最佳包合工艺为挥发油与β-CD比例1∶11,包合温度60℃,包合时间1h,挥发油包合率达96.84％.表征试验证实,挥发油β-CD包合物已经形成.结论:行气那尼花挥发油β-CD包合物制备工艺稳定可行,可推广于产业化应用.
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| 关 键 词： | 行气那尼花颗粒 挥发油 β-环糊精包合物 均匀设计试验 |
| 收稿时间： | 2013/1/30 0:00:00 |
Optimization of Inclusion Technology for Volatile Oil from Xingqi Na'nihua Granules by Uniform Design |
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| NAN Jing,LIU Cheng,YE Xiao-chuan and LIU Yan-wen.Optimization of Inclusion Technology for Volatile Oil from Xingqi Na'nihua Granules by Uniform Design[J].China Journal of Experimental Traditional Medical Formulae,2013,19(13):53-56. |
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| Authors: | NAN Jing LIU Cheng YE Xiao-chuan and LIU Yan-wen |
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| Institution: | Pharmacy Faculty,Hubei University of Chinese Medicine,Wuhan 430065,China;Pharmacy Faculty,Hubei University of Chinese Medicine,Wuhan 430065,China;Pharmacy Faculty,Hubei University of Chinese Medicine,Wuhan 430065,China;Hubei Province Key Laboratory of Resources Science and Chemistry in Traditional Chinese Medicine,Wuhan 430065,China;Pharmacy Faculty,Hubei University of Chinese Medicine,Wuhan 430065,China;Hubei Province Key Laboratory of Resources Science and Chemistry in Traditional Chinese Medicine,Wuhan 430065,China |
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| Abstract: | |
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| Keywords: | Xingqi Na'nihua granules volatile oil β-cyclodextrin inclusion complex uniform design test |
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