基于二苯乙烯类为主要活性成分的虎杖药理作用研究进展

目的:在简要阐述虎杖化学成分的基础上,阐明以二苯乙烯类为主要生物活性成分的虎杖药理作用研究现状。方法:查阅国内外近10年相关资料81篇并对其进行汇总、分析、综述。结果:至目前为止,已发现的化学成分主要有二苯乙烯类、蒽醌类、黄酮类、鞣质、多糖等;药理研究显示,虎杖有抗艾滋病、抗癌、抗菌、抗病毒、抗炎、降血糖、抗组织(心、脑、肺、肾)损伤、抗脂质过氧化、抗骨质疏松、神经保护、降血脂、保肝等广泛药理作用;虎杖所含的二苯乙烯类成分是其发挥众多生物活性的主要物质基础,蒽醌类成分在其较多生物活性的发挥上也起到了一定的作用。结论:中药虎杖药理作用广泛,极有开发价值,尤其在抗艾滋病和抗癌方面。

Research Progress in Pharmacological Actions of Rhizomn Polygoni Cuspidati Based on Stilbene Compounds as Main Bioactive Components

Objective: To clarify the research progress in pharmacological actions of Rhizomn Polygoni Cuspidati, having the main bioactive components of stilbene compounds, on the basis of introducing its chemical components briefly. Method: Looked through the related literatures from domestic and abroad, analyzed and reviewed on them. Result: Up to now, the chemical components isolated from P. cuspidatum mainly include stilbenes, anthraquinones, flavonoids, tannins, polysaccharides, etc. Pharmacological results show that it has effects on anti-HIV, anticancer, antimicrobial, antivirus, anti-inflammation, anti-diabetes, anti-tissue (heart, brain, lung, kidney) damages, anti-lipid peroxidation, anti-osteoporosis, neuroprotection, hypolipidemic, hepatoprotection and so on. Stilbene compounds are the main and key bioactive components of various pharmacological actions, and meanwhile anthraquinones can play important roles to some extent in the actions of P. cuspidatum. Conclusion: P. cuspidatum has wide ranges of pharmacological actions and great exploiting values in various aspects, especially in anti-HIV and anticancer. The present review can provide significant reference for further studies and exploitations of P. cuspidatum.