10味平性活血药"双向适用" 药效学试验的贝叶斯分析

目的: 对已获得的药效学试验数据进行挖掘和分析,验证平性活血药"双向适用"的药性特征。 方法: 采用Weka 3.6.2软件进行贝叶斯分析,按数据预处理、属性选择、建立相关贝叶斯网络模型、分类预测的步骤进行数据挖掘与分析。 结果: 在瘀热互结证中,3类药性中药组与模型组分类,AUC大小顺序为平性药>寒性药>热性药;在寒凝血瘀证中,3类药性中药组与模型组分类,AUC大小依次为热性药>平性药>寒性药。 结论: 对瘀热互结证,平性活血药与寒性活血药具有类似治疗效果;对寒凝血瘀证,平性活血药与热性活血药具有类似治疗效果;在一定程度上证明平性药具有"双向适用"的药性特征。

Bayesian Analysis on Two-way Application Pharmacodynamic Trial of 10 Chinese Activating Blood Herbs with Neutral Property

Objective: By analyzing and mining these obtained numerous pharmacodynamic test data, finally testify the characteristic of two-way applicable of Chinese herbs with neutral property. Method: Weka analysis software and bayesian network analysis method were used in this research. The procedure was data preprocessing, attribute selection, building related Bayesian network model, classification forecasting. Result: In the heat stagnation and blood stasis syndrome, AUC values of classification between three different herb property groups and model control group were in order of neutral property herb>cold property herb>hot property herb.But in the cold stagnation and blood stasis syndrome, the order was hot property herb>neutral property herb>cold property herb. Conclusion: To treat heat stagnation and blood stasis syndrome, the effect of neutral property herb and cold property herb were better than hot property herb, even neutral property herb was better than cold property herb.To treat cold stagnation and blood stasis syndrome, the effect of neutral property herb and hot property herb were better than cold property herb.These results proved that neutral property herbs were two-way applied to cold and hot syndrome, which did not rely on concocted degeneration or compatibility.