| 藏族药甘青乌头化学成分研究(IV) |
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| 引用本文： | 杨丽华,李春,林丽美,王智民,李钟.藏族药甘青乌头化学成分研究(IV)[J].中国实验方剂学杂志,2016,22(4):39-44. |
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| 作者姓名： | 杨丽华 李春 林丽美 王智民 李钟 |
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| 作者单位： | 广东药学院, 广州 510006,中国中医科学院 中药研究所, 中药质量控制技术国家工程实验室, 北京 100700,湖南中医药大学, 长沙 410208,中国中医科学院 中药研究所, 中药质量控制技术国家工程实验室, 北京 100700,广东药学院, 广州 510006 |
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| 基金项目： | 北京市自然科学基金项目(7132152);中央级公益性科研院所基本科研业务费专项(ZZ070828) |
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| 摘 要： | 目的: 研究藏族药甘青乌头全草的化学成分。方法: 采用多种现代色谱技术进行分离纯化,并通过理化性质、波谱分析(1D,2D-NMR和MS)及与文献对比的方法进行结构鉴定。结果: 分离并鉴定了17个化合物,分别为异光黄素(1),对羟基桂皮酸(2),苯甲酸(3),对羟基苯乙胺(4),对羟基苯乙醇(5),尼泊金丁酯(6),腺苷(7),3-p-hydroxyphenyl]-propionic acid amide(8),hetisine(9),关附辛素(10),红景天苷(11),环(异亮-亮)二肽(12),苯丙氨酸(13),3-(4-aminophenyl)prop-2-enoic acid(14),N-oxide hordenine(15),(2R,3R)-2,3,4-三羟基丁酸(16)和N-甲基酪胺(17)。结论: 其中化合物 1~4,6~8和12~17 为首次从甘青乌头中分离得到。
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| 关 键 词： | 甘青乌头 化学成分 水溶性生物碱 |
| 收稿时间： | 2015/5/30 0:00:00 |
Chemical Constituents from Whole Plants of Aconitum tanguticum (IV) |
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| YANG Li-hu,LI Chun,LIN Li-mei,WANG Zhi-min and LI Zhong.Chemical Constituents from Whole Plants of Aconitum tanguticum (IV)[J].China Journal of Experimental Traditional Medical Formulae,2016,22(4):39-44. |
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| Authors: | YANG Li-hu LI Chun LIN Li-mei WANG Zhi-min and LI Zhong |
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| Institution: | Guangdong Pharmaceutical University, Guangzhou 510006, China,National Engineering Laboratory for Quality Control Technology of Chinese Herbal Medicines, Institute of Chinese Materia Medica, China Academy of Chinese Medicine Sciences, Beijing 100700, China,Hunan University of Traditional Chinese Medicine, Changsha 410208, China,National Engineering Laboratory for Quality Control Technology of Chinese Herbal Medicines, Institute of Chinese Materia Medica, China Academy of Chinese Medicine Sciences, Beijing 100700, China and Guangdong Pharmaceutical University, Guangzhou 510006, China |
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| Abstract: | Objective: To study the chemical constituents from Aconitum tanguticum. Method: The chemical constituents were isolated and purified by using a combination of modern chromatographic techniques, and their structures were determined through spectral analysis(1D, 2D-NMR and MS) and literature comparison. Result: Seventeen compounds were isolated and identified as isolumichrome(1), p-hydroxycinnamic acid(2), benzoic acid(3), p-hydroxy phenylethylamine(4), p-hydroxy phenylethanol(5), butylparaben(6), adenosine(7), 3-p-hydroxyphenyl]-propionic acid amide(8), hetisine(9), guanfu base H(10), salidroside(11), cyclo-(ile-leu)(12), phenylalanine(13), 3-(4-aminophenyl)prop-2-enoic acid(14), N-oxide hordenine(15),(2R,3R)-2,3,4-trihydroxy-butanoic acid(16), and N-methyltyramine(17). Conclusion: Compounds 1-4, 6-8 and 12-17 were isolated from A. tanguticum for the first time. |
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| Keywords: | Aconitum tanguticum chemical constituents water-soluble alkaloids |
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