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栀子环烯醚萜苷治疗脑缺血损伤的作用机制研究
引用本文:杨军宣,张海燕,赵成城,黄勤挽,杨明.栀子环烯醚萜苷治疗脑缺血损伤的作用机制研究[J].中国实验方剂学杂志,2010,16(6):277-280.
作者姓名:杨军宣  张海燕  赵成城  黄勤挽  杨明
作者单位:1. 成都中医药大学药学院,成都,611137
2. 江西中医学院现代中药制剂教育部重点实验室,南昌,330004
3. 成都中医药大学药学院,成都,611137;江西中医学院现代中药制剂教育部重点实验室,南昌,330004
摘    要:目的: 探讨近几年来栀子环烯醚萜苷治疗脑缺血损伤的作用机制,为栀子环烯醚萜苷类成分的进一步研究和应用提供参考。 方法: 查阅国内外相关文献并进行归纳、总结。 结果: 环烯醚萜苷类成分是栀子药材的主要化学成分。研究表明,它不仅有明显的保肝利胆、解热、镇静等作用,而且对缺血性脑损伤亦有保护作用。关于栀子环烯醚萜苷类成分对缺血性脑损伤的保护作用研究较多,其作用机制是多方面的。 结论: 栀子环烯醚萜苷治疗脑缺血损伤的作用机制有待进一步研究。

关 键 词:栀子环烯醚萜苷  脑缺血  作用机制  研究进展
收稿时间:1/8/2010 12:00:00 AM

Progress in Studies on Mechanism of Gardenia Iridoid Glycosides for Cerebral Ischemic Injury
YANG Jun-xuan,ZHANG Hai-yan,ZHAO Cheng-cheng,HUANG Qin-wan and YANG Ming.Progress in Studies on Mechanism of Gardenia Iridoid Glycosides for Cerebral Ischemic Injury[J].China Journal of Experimental Traditional Medical Formulae,2010,16(6):277-280.
Authors:YANG Jun-xuan  ZHANG Hai-yan  ZHAO Cheng-cheng  HUANG Qin-wan and YANG Ming
Institution:College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China;Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China;College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China;College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China;College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China;Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China
Abstract:Objective: To review the progress in studies on mechanism of gardenia iridoid glycosides for treatment of cerebral ischemic injury, so as to provide more information on gardenia iridoid glycosides for further research and application. Method: The literatures published home and abroad in recent years were consulted and summarized. Result: Gardenia iridoid glycosides are the main chemical components in Fructus Gardeniae. Modern studies show that gardenia iridoid glycosides not only have protective effects in liver gallbladder, antipyretic, sedative and other effects, but also have protective effects against ischemic brain injury. Currently there are more studies about gardenia iridoid glycosides against ischemic brain injury, and the mechanism is multifaceted. Conclusion: More studies are needed on the mechanism of gardenia iridoid glycosides for treatment of cerebral ischemic injury.
Keywords:gardenia iridoid glycosides  cerebral ischemia  mechanism  research progress
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