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青天葵中黄酮类化合物的体外抗肿瘤实验研究
引用本文:甄汉深,周燕园,袁叶飞,梁臣艳,丘琴,钟振国,张薇薇.青天葵中黄酮类化合物的体外抗肿瘤实验研究[J].中国实验方剂学杂志,2008,14(3):36-38.
作者姓名:甄汉深  周燕园  袁叶飞  梁臣艳  丘琴  钟振国  张薇薇
作者单位:广西中医学院,广西,南宁,530001
基金项目:国家自然科学基金项目(30160095)与地区联合资助,国家人事部留学回国人员资助项目(人发[2002]99号),广西人事厅广西“新世纪十百千人才工程”资助项目(2001209)
摘    要:目的:观察青天葵中黄酮类化合物鼠李柠檬素和鼠李秦素对7种肿瘤细胞的抑制作用。方法:采用MTT法测定了它们各自对白血病细胞株L1210和P388D1、宫颈癌细胞株Hela、人胃癌细胞株SGC7901、黑色素瘤细胞株B16、神经性肿瘤细胞株NG108-15、人肝癌细胞株Hele7404的生长抑制情况。结果:鼠李柠檬素对L1210,P388D1,Hela,B16,NG108-15和Hele7404 6种瘤株都有直接抑制作用,而且都随着浓度的增加,抑制作用增强。但鼠李柠檬素对瘤株SGC7901基本无抑制作用,鼠李秦素对7种瘤株均无抑制作用。结论:鼠李柠檬素具有一定的体外抗肿瘤作用,初步确定鼠李柠檬素为青天葵抗肿瘤的活性成分之一。鼠李秦素基本无抗肿瘤作用。

关 键 词:黄酮  鼠李柠檬素  鼠李秦素  体外抗肿瘤作用
文章编号:1005-9903(2008)03-0036-03
收稿时间:7/3/2007 12:00:00 AM
修稿时间:2007年7月3日

Study on the Anticancer Effect in Vitro of Flavonoids Compounds Obtained from Nervilia fordii(Hance) Schltr.
ZHEN Han-shen,ZHOU Yan-yuan,YUAN Ye-fei,LIANG Chen-yan,QIU Qin,ZHONG Zhen-guo,ZHANG Wei-wei.Study on the Anticancer Effect in Vitro of Flavonoids Compounds Obtained from Nervilia fordii(Hance) Schltr.[J].China Journal of Experimental Traditional Medical Formulae,2008,14(3):36-38.
Authors:ZHEN Han-shen  ZHOU Yan-yuan  YUAN Ye-fei  LIANG Chen-yan  QIU Qin  ZHONG Zhen-guo  ZHANG Wei-wei
Institution:Guangxi Traditional Chinese Medical University,Nanning,Guangxi 530001,China
Abstract:Objective: To assay the inhibitive effect on seven kinds of human tumor cells of rhamnocitrin and rhamnazin flavonoids compounds obtained from Nervilia fordii(Hance) Schltr.Methods: Anticancer experiment in vitro was done by applying MTT method to iveatigation of rhamnocitrin and rhamnazin on human leukemia L1210 and P388D1,uterine carcinoma Hela,gastric adenocarcinoma SGC7901,inhibiting cell B16,neuromas NG108-15,Human hepatoma Hele7404.Results: Rhamnocitrin inhibited the growth of L1210,P388D1,Hela,B16,NG108-15 and Hele7404 human tumor cells.With the concentration elevated,inhibiting action increased.But rhamnocitrin had no effects on SGC7901,and rhamnazin had no effects on seven kinds of human tumor cells.Conclusion: Rhamnocitrin,one of the active principles of Nervilia fordii(Hance) Schltr,inhibited the growth of human tumor cells in vitro.However,rhamnazin had no effects.
Keywords:flavonoids  rhamnocitrin  rhamnazin  anticancer effect in vitro
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