代谢组学在中医药研究中的应用进展

目的:介绍近年来代谢组学在中医药研究中的应用。方法:通过检索中国知网数据库近年来代谢组学在中医药研究中应用的文献32篇,对该领域进行总结归纳。结果:代谢组学能够揭示中医药治疗疾病过程中生物体系内所发生的代谢物的变化和代谢通路及途径的改变,强调从整体角度研究生物体的功能水平,与中医理论的"整体观"相一致,符合中医药多组分、多靶点、整体综合效应的特点。广泛应用中医证候、经络与针刺、中药药效、作用机制和物质基础以及中药安全性评价等领域。在中医药研究中应用代谢组学的方法,应进一步提高分析测定的水平、将适用的分析技术进行整合,实现多种化合物的同时检测;完善代谢组学数据库的建设;加强代谢组学研究中的数据处理与分析的整合,满足其高通量、大规模的数据处理要求。结论:代谢组学应用于中医药研究具有广阔的前景。

Application Progress of Metabonomics in Study of Traditional Chinese Medicine

Objective: To summarize the application progress of metabonomics in study of traditional Chinese medicine(TCM). Method: Literature about application of metabonomics in the study of TCM in recent years was reviewed. Result: Metabonomics could reveal the changes of metablites and metabolic pathway in the biological systems when using TCM to cure diseases. It laid stress on the studying the function level of organism in an overall perspective, which was in accord with the TCM theory of viewing human body as the unity and similar to its characteristics of multiple-components and targets and whole, combined effects also. It was widely used in the research of TCM syndromes, meridians and acupuncture, effect, mechanism, material basis and safety evaluation of TCM. When metabonomics was used to study TCM, it was important to raise further analysis and determination standards and to integrate useful analysis technology to make simultaneous detection of various chemicals coming true. Metabonomics database should be perfected also. It was vital to enhance the intergration of data processing and analysising to meet the high throughput and mass requirement in the study of metabonomics. Conclusion: Metabonomics has a vast potential for future application in the research of TCM.