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脂脉宁对动脉粥样硬化家兔氧化应激反应及LDL-R, VCAM-1基因表达的影响
引用本文:刘应柯,张玉峰,刘尚岭,张希卿.脂脉宁对动脉粥样硬化家兔氧化应激反应及LDL-R, VCAM-1基因表达的影响[J].中国实验方剂学杂志,2011,17(20):214-217.
作者姓名:刘应柯  张玉峰  刘尚岭  张希卿
作者单位:1. 中国人民解放军第153中心医院,郑州,450042
2. 河南省中医院,郑州,450002
基金项目:河南省自然科学基金项目(061142400)
摘    要:目的:探讨脂脉宁抗动脉粥样硬化(AS)的作用机制。方法:用高脂饲料复制家兔AS模型,于4周后再灌服脂脉宁4周,检测血脂、氧化指标及主动脉低密度脂蛋白受体(LDL-R)mRNA及血管细胞黏附分子-1(VCAM-1)mRNA的表达。结果:模型组血脂4项及超氧化物歧化酶(SOD)、丙二醛(MDA)均明显较空白组升高,谷胱甘肽(GSH)、谷胱甘肽过氧化物酶(GSH-Px)降低,主动脉内膜、斑块明显增厚;脂脉宁0.375,0.188 g.kg-1血脂及MDA含量均明显较模型组降低,GSH,GSH-Px升高,动脉斑块减小,高剂量组效果更明显。模型组LDL-R mRNA表达明显降低,VCAM-1 mRNA表达升高;给药2组LDL-RmRNA表达则明显升高,VCAM-1 mRNA表达降低,高剂量组尤为明显。结论:脂脉宁抗AS作用与其调整脂质代谢、抗氧化及调控LDL-R mRNA及VCAM-1 mRNA表达有关。

关 键 词:脂脉宁  动脉粥样硬化  血管细胞黏附分子-1  低密度脂蛋白受体  氧化反应
收稿时间:2011/4/11 0:00:00

Effect of Zhimaining on Oxidative Stress and Gene Expression of LDL-R, VCAM-1 in Rabbit with Atherosclerosis
LIU Ying-ke,ZHANG Yu-feng,LIU Shang-ling and ZHANG Xi-qing.Effect of Zhimaining on Oxidative Stress and Gene Expression of LDL-R, VCAM-1 in Rabbit with Atherosclerosis[J].China Journal of Experimental Traditional Medical Formulae,2011,17(20):214-217.
Authors:LIU Ying-ke  ZHANG Yu-feng  LIU Shang-ling and ZHANG Xi-qing
Institution:Hospital 153 of PLA, zhengzhou 450042, China;Henan College of Traditional Chinese Medicine, Zhengzhou 450002, China;Hospital 153 of PLA, zhengzhou 450042, China;Hospital 153 of PLA, zhengzhou 450042, China
Abstract:Objective: To discuss the anti-atherosclerosis mechanism of Zhimaining. Methed: Rabbit atherosclerosis model was reproduced with high fat diet. Zhimaining was fed for 4 weeks when hyperlipidemia had been taken shape in 4 weeks, Index of lipid,oxidation,Low density lipoprotein-R(LDL-R) mRNA and VCAM-1 mRNA were detected. Result: There was a significient increase in lipid,superoside dismatase(SOD) and malandiavdehyde(MDA) and decrease in Gluathine(GSH),Glutathine peroxidase(GSH-Px) in model group compared with contral group; there was a significient increase in aorta endometrial and plaque in model group compared with contral group. A very significient decrease of lipid and MDA and increase of GSH,GSH-Px in high dose (0.375 g·kg-1) and low dose(0.188 g·kg-1) group were manifested compared with control group. There was a significient increase of the expression of VCAM-1 mRNA and decrease of the expression of LDL-R mRNA both in the Zhimaining groups compared with contral group. Conclution :The anti-atherosclerosis mechanism of Zhimaining may be related with regulating the antioxidant and metabolism of lipid and the expression of LDL-R mRNA and VCAM-1 mRNA.
Keywords:Zhimaining  atherosclerosis  VCAM-1  LDL-R  oxidation
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