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| 溃疡平对乙酸性胃溃疡大鼠胃黏膜血流量及血清ET-1,NO含量的影响 | |
| 引用本文： | 赵红晔,曹军,王月飞,赫灵菊,周丽,卢长柱,王滨.溃疡平对乙酸性胃溃疡大鼠胃黏膜血流量及血清ET-1,NO含量的影响[J].中国实验方剂学杂志,2011,17(17):213-215. |
| 作者姓名： | 赵红晔 曹军 王月飞 赫灵菊 周丽 卢长柱 王滨 |
| 作者单位： | 1. 齐齐哈尔医学院生理教研室,黑龙江齐齐哈尔,161006 2. 中国中医科学院中药研究所,北京,100700 3. 齐齐哈尔市富拉尔基区中医医院,黑龙江齐齐哈尔,161041 |
| 基金项目： | 黑龙江省中医管理局项目(ZHY10-Z107) |
| 摘 要： | 目的:观察溃疡平对乙酸性胃溃疡大鼠胃黏膜血流量(GMBF)及血清内皮素-1(ET-1)和一氧化氮(NO)含量的影响。方法:采用改良Okabe法制备大鼠慢性乙酸胃溃疡模型,随机分为:正常组、模型组、溃疡平低、中、高剂量组(1.40,2.80,5.60 g.kg-1 i,g)和盐酸雷尼替丁组(2.83×10-2 g.kg-1 i,g)6组。给药14 d后,运用MP150多道生理记录系统中的LDF100C激光多普勒血流测定模块测定溃疡周边部的GMBF;ELISA法检测血清ET-1的含量;硝酸盐还原酶法检测血清NO含量。结果:与模型组相比,溃疡平高剂量组GMBF明显增多(P<0.05),血清ET-1含量明显降低(P<0.01),血清NO含量明显升高(P<0.05);与盐酸雷尼替丁组相比,溃疡平高剂量组GMBF明显增多(P<0.05),血清ET-1含量明显降低(P<0.01),血清NO含量明显升高(P<0.05)。结论:溃疡平刺激NO的合成和释放,反馈性抑制ET-1的释放,从而增加GMBF,这可能是其加速胃溃疡愈合和改善溃疡愈合质量(QOUH)的作用机制之一。 |
| 关 键 词： | 溃疡平 胃黏膜血流 内皮素-1 一氧化氮 |
| 收稿时间： | 2011/4/25 0:00:00 |
Effects of Chinese Medicine Kuiyangping on Gastric Mucosal Blood Flow and the Serum Concentration of ET-1 and NO in Rats with Acetic Acid-induced Gastric Ulcer |
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| ZHAO Hong-ye,CAO Jun,WANG Yue-fei,HE Ling-ju,ZHOU Li,LU Chang-zhu and WANG Bin.Effects of Chinese Medicine Kuiyangping on Gastric Mucosal Blood Flow and the Serum Concentration of ET-1 and NO in Rats with Acetic Acid-induced Gastric Ulcer[J].China Journal of Experimental Traditional Medical Formulae,2011,17(17):213-215. | |
| Authors: | ZHAO Hong-ye CAO Jun WANG Yue-fei HE Ling-ju ZHOU Li LU Chang-zhu and WANG Bin |
| Institution: | Department of Physiology, Qiqihar Medical University, Qiqihar 161006, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Department of Physiology, Qiqihar Medical University, Qiqihar 161006, China;Fulaerji Traditional Chinese Medicine Hospital, Qiqihar 161041, China;Department of Physiology, Qiqihar Medical University, Qiqihar 161006, China;Department of Physiology, Qiqihar Medical University, Qiqihar 161006, China;Department of Physiology, Qiqihar Medical University, Qiqihar 161006, China |
| Abstract: | |
| Keywords: | Kuiyangping GMBF ET-1 NO |
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