利用文本挖掘技术探索中成药和西药治疗2型糖尿病的用药规律

目的:利用文本挖掘技术,探索中成药、西药治疗2型糖尿病的用药规律以及中成药与西药联合应用情况。方法:在中国生物医学文献数据库(CBM)中收集治疗2型糖尿病的相关文献,建立Access数据库,运用SQL对数据进行处理,结合人工降噪后,分析中成药、西药对2型糖尿病的治疗用药规律。结果:消渴丸、丹参注射液、黄芪注射液、六味地黄丸、玉泉丸等中成药为治疗2型糖尿病文献中出现的高频药物,滋肾养阴是中医治疗2型糖尿病的重要法则。二甲双胍、胰岛素泵、皮下注射胰岛素、罗格列酮、瑞格列奈、格列齐特、格列吡嗪、阿卡波糖、吡格列酮等药物或治疗方式,为治疗2型糖尿病文献中出现的高频西药或治疗方式。玉泉丸与二甲双胍联用,六味地黄丸与格列齐特联用是最常用的中西药联用组合。结论:利用文本挖掘的方法,从文献报道频数方面提供中西医治疗2型糖尿病的用药规律,为临床选药和基础研究提供参考,中西药联合应用在药物作用机制、适应症等方面,还值得进一步研究。

Exploring Rules of Chinese Patent Medicines and Western Medicines in Treatment of Type 2 Diabetes with Text Mining

Objective: To explore the rules of Chinese patent medicines, western medicines, and their combination rules in the treatment of type 2 diabetes through data mining. Method: We queried and downloaded the data on type 2 diabetes from Sino Med on March, 2011.By transferring semi-structured data structured database of Microsoft SQL was set into, we got the raw data for data mining. By executing the algorithm of discrete derivaties, we got some simple and meaningful networks of type 2 diabetes. In cytoscape, these networks were visualized. Result: In the treatment of type 2 diabetes, Chinese patent medicines, i.e., Xiaoke Wan, Salvia Miltiorrhiza Injection, Radix Astragali Injection, Liuweidihuang Wan, and Yuquan Wan were most frequently used. among all the western medicines, metformin, insulin pump, subcutaneous injection of insulin, rosiglitazone, repaglinide, gliclazide, glipizide, acarboseare, and pioglitazone are most concerned in the treatment of type 2 diabetes. Conclusion: Rules of Chinese patent medicines, west medicines, and their combinations in the treatment of type 2 diabetes are proposed in this paper.