麻芍平喘汤对支气管哮喘冷哮证患者中医症状和生存质量的影响

目的:评价麻芍平喘汤对支气管哮喘冷哮证患者中医症状、生存质量及外周血嗜酸性粒细胞(Eos)和血清炎症因子白细胞介素-6(IL-6),白细胞介素-8(IL-8)的影响。方法:选取2018年1月至2019年12月安徽省中医院呼吸门诊就诊的支气管哮喘冷哮证患者67例,随机分为对照组和观察组。对照组予布地奈德福莫特罗粉吸入剂吸入等基础治疗,观察组在对照组基础上予麻芍平喘汤口服。两组均连续干预7 d。观察记录两组哮喘患者一般情况、中医症状积分,哮喘控制问卷(ACQ)-7评分,Marks-哮喘生存质量问卷(Marks-AQLQ)评分;采用血细胞分析仪检测外周血Eos计数,酶联免疫吸附测定(ELISA)检测受试者血清IL-6,IL-8的含量。结果:两组中医症状疗效总有效率均为100%(30/30),观察组疗效更明显(Z=-2.169,P<0.05)。治疗后,两组中医症状积分均较治疗前显著降低(P<0.01),观察组喉中痰鸣、咯痰、咳嗽、畏寒肢冷证候积分组间均明显低于对照组(P<0.05)。治疗后,两组ACQ-7评分,Marks-AQLQ评分均较治疗前显著降低(P<0.01),观察组ACQ-7评分,Marks-AQLQ评分组间比较差异无统计学意义。治疗后,两组外周血Eos计数和血清IL-6,IL-8含量均较治疗前显著降低(P<0.01),观察组外周血Eos计数和血清IL-6,IL-8含量均明显低于对照组(P<0.05)。结论:麻芍平喘汤联合布地奈德福莫特罗粉吸入治疗能有效提高哮喘冷哮证临床有效率,改善哮喘中医症状表现,ACQ-7评分,Marks-AQLQ评分,外周血Eos计数,血清炎症因子含量。

Effect of Mashao Pingchuan Decoction on Traditional Chinese Medicine Symptoms and Quality of Life in Patients with Cold Asthma of Bronchial Asthma

Objective: To evaluate the effect of Mashao Pingchuan decoction on traditional Chinese medicine(TCM)symptoms,quality of life,peripheral blood eosinophils(Eos)and serum inflammatory factors interleukin-6(IL-6)and interleukin-8(IL-8)in patients with cold asthma syndrome of bronchial asthma.Method: A total of 67 patients with cold asthma who attended the Respiratory Clinic of Anhui Provincial Hospital of TCM from January 2018 to December 2019 were selected and randomly divided into a control group and an observation group. The control group was given basic treatments such as budesonide formoterol powder inhalation,and the observation group was given Mashao Pingchuan decoction on the basis of the control group.Both groups intervened for 7 consecutive days. Observe and record the general condition,TCM symptom score,asthma control questionnaire(ACQ)-7 score,Marks-asthma quality of life questionnaire(Marks-AQLQ)score of the two groups of asthma patients,the peripheral blood Eos count was measured by hematology analyzer,and the serum IL-6 and IL-8 levels of the subjects were measured by enzyme-linked immunosorbent assay(ELISA).Result: The total effective rate of TCM symptoms in the two groups was 100%(30/30),and the effect in the observation group was more obvious(Z=-2.169,P<0.05). After treatment,the scores of TCM symptoms in the two groups were significantly lower than those before treatment(P<0.01). The scores of phlegm in the throat,expectoration,cough,and chills in the observation group were lower than those in the control group(P<0.05).After treatment,the ACQ-7 scores and Marks-AQLQ scores of the two groups were significantly lower than before treatment(P<0.01). There was no statistically significant difference between the observation group and the ACQ-7 scores and Marks-AQLQ scores. After treatment,the peripheral blood Eos counts and serum IL-6 and IL-8 levels in the two groups were significantly lower than before treatment(P<0.01). Peripheral blood Eos count and serum IL-6 and IL-8 contents in observation group were lower than those in control group(P<0.05).Conclusion: Mashao Pingchuan decoction combined with budesonide formoterol powder inhalation can effectively improve the clinical effectiveness of asthma(cold asthma),improve the symptoms of asthma in TCM,ACQ-7 score,Marks-AQLQ score,peripheral blood Eos count,serum inflammatory factor content.