泻心汤对正常和多种糖尿病模型动物的降血糖作用

观察泻心汤对正常、四氧嘧啶（ＡＬＸ）致糖尿病（ＤＭ）小鼠及地塞米松致胰岛素抵抗（ＩＲ）、糖耐量减退（ＩＧＴ）、模型大鼠的影响。结果表明，泻心肠能拮抗ＡＬＸ诱导的小鼠高血糖，明显降低正常小鼠ＡＬＸ－ＤＭ模型小鼠的空腹血糖（ＦＢＧ），地塞米松致ＩＲ大鼠模型的ＩＧＴ，降低病鼠的ＦＢＧ及口服葡萄糖（ＯＧＴＴ）后２ｈ血糖（２ｈＢＧ），提示泻心肠具有类似磺脲类药物和双胍类药物的降糖作用。

Effects of Xiexin Tang on educing the Level of Blood Glucose in Animal models of Normal and Diabetes Mellitus

Effects of Xiexin Tang on the level of blood glucose in serial animal models of normal and diabetes mellitus were studied,and its mechanism on reducing blood glucose were preliminarily explored.Fasting blood glucose(FBG) in normal mice,alloxan induced hyperglycemia or diabetes mellitus (DM),two hours blood glucose (2hBG) after oral glucose tolerance test(OGTT)in rats by dexamethasone(DX) induced insulin resistance (IR) and impaired glucose tolerance(IGT) were determined.Results showed the formula can inhibit the hyperglycemia by ALX induced mice,decrease level of FBG in normal and DM mice obviously,improve IGT by DX induced IR rats,reduce FBG and 2hBG after OGTT.The formula has a similar hypoglycemic action of metformin and gliclazide.