3个厂家来源黄芪皂苷提取物对淋巴细胞增殖的影响

目的:考察不同来源黄芪皂苷提取物对体外脾淋巴细胞增殖的影响。方法:MTT法分别检测3批黄芪皂苷提取物对正常脾淋巴细胞、ConA诱导脾淋巴细胞增殖的影响。结果:各批样品对正常脾淋巴细胞增殖均有显著抑制作用,且高质量浓度(166 mg·L-1)抑制作用最强;各批样品对经ConA诱导的脾淋巴细胞,质量浓度为16.6～166 mg·L-1时有显著抑制作用,质量浓度为1.66 mg·L-1时有明显促增殖作用。结论:不同来源黄芪皂苷提取物的免疫活性作用趋势相同,但作用强度存在差异。

Influence of Astragalosides from Three Producers on Lymphocyte Proliferation

Objective: To investigate the influence of astragalosides from three producers on lymphocyte proliferation. Method: The influence of astragalosides from three producers on lymphocyte proliferation was examined with normal lymphocytes and lymphocytes activated by ConA by MTT. Result: All samples remarkably restrain normal lymphocyte proliferation,possess the best effects under 166 mg ·L^-1,remarkably restrain the proliferation of lymphocyte activated by ConA under 16.6-166 mg ·L^-1,and remarkably promote the proliferation of lymphocyte under 1.66 mg ·L^-1. Conclusion: Astragalosides from different producers show similar tendency in immunocompetence,however,with different intensity of action.