淫羊藿总黄酮及淫羊藿苷的心血管保护作用及机制研究进展

淫羊藿总黄酮是淫羊藿主要活性成分,而淫羊藿苷是淫羊藿总黄酮中的重要活性物质之一,具有抗炎、抗肿瘤、抗骨质疏松、保护心脑血管等广泛的药理作用。本文通过系统查阅中国知网、Pub Med、Springer Link等国内外文献数据库,收集淫羊藿总黄酮及淫羊藿苷对心血管保护作用方面的文献,获取第一手资料,并对其进行分析和归纳整理。发现淫羊藿总黄酮及淫羊藿苷保护心血管作用涉及抗动脉粥样硬化、抗高血压、对血流动力学及血液流变学影响、抗心肌缺血、抗心力衰竭等方面的作用,在细胞因子、细胞内信号通路层面对其作用机制也进行了不同深度的研究。本文内容详实可靠,为以淫羊藿总黄酮及淫羊藿苷为主要药效成分的新药研究提供文献资料,具有重要的理论价值和现实意义。

Research Advances of Cardiovascular Protection and Their Mechanisms of Total Flavonoids and Icariin from Epimedii Folium

Total flavonoids are main active components of epimedium and icariin is one of the most important active substances of epimedium total flavonoids, which has wide pharmacological effects such as anti-inflammation, anti-tumor, anti-osteoporosis, and cardio cerebral vascular protection, et al. In this paper, documents of epimedium total flavonoids and icariin about cardiovascular protection were collected from domestic and international literature database such as CNKI, PubMed and SpringerLink et al. The research progress mainly related to anti-atherosis, anti-hypertension, effects on hemodynamics and hemorrheology, anti-myocardial ischemia, anti-heart failure, we also collected data for cytokine and intracellular signaling pathways mechanisms and analyzed them at different depth. This paper has important theoretical value and practical significance for the new drug of epimedium total flavonoids and icariin and provides reliable literature information for the further studies.