| 三七总皂苷治疗缺血性脑卒中研究进展 |
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| 引用本文： | 刘抒雯,刘敬霞,虎喜成,任非非,刘超,甘佳乐.三七总皂苷治疗缺血性脑卒中研究进展[J].中国实验方剂学杂志,2015,21(15):217-220. |
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| 作者姓名： | 刘抒雯 刘敬霞 虎喜成 任非非 刘超 甘佳乐 |
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| 作者单位： | 宁夏医科大学 研究生院, 银川 750004,宁夏医科大学 中医学院, 银川 750004,宁夏医科大学 研究生院, 银川 750004,宁夏医科大学 研究生院, 银川 750004,宁夏医科大学 研究生院, 银川 750004,宁夏医科大学 研究生院, 银川 750004 |
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| 基金项目： | 国家自然科学基金项目(81260569);“十二五”国家科技支撑计划项目(SQ2013SF12E02181) |
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| 摘 要： | 探讨三七总皂苷对缺血性脑卒中的干预效果、作用机制。查阅近年来国内外有关三七总皂苷治疗缺血性脑卒中的药理作用及实验研究等方面文献,并对其进行分析、归纳与总结。文献研究结果提示三七总皂苷及其有效成分对治疗缺血性脑卒中具有明显保护作用。三七总皂苷及其有效成分在治疗缺血性脑卒中能够抑制炎症因子表达、抗自由基毒性损伤、抗血小板聚集及抑制凋亡调控基因、促进周围神经细胞再生等作用,有望成为治疗缺血性脑卒中的有效药物,为今后进一步的开发利用提供了新的思路。
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| 关 键 词： | 三七总皂苷 有效成分 缺血性脑卒中 作用机制 |
| 收稿时间： | 2014/11/30 0:00:00 |
Research Advances in Treatment of Cerebral Ischemic Stroke by Notoginseng Radix et Rhizoma Saponins |
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| LIU Shu-wen,LIU Jing-xi,HU Xi-cheng,REN Fei-fei,LIU Chao and GAN Jia-le.Research Advances in Treatment of Cerebral Ischemic Stroke by Notoginseng Radix et Rhizoma Saponins[J].China Journal of Experimental Traditional Medical Formulae,2015,21(15):217-220. |
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| Authors: | LIU Shu-wen LIU Jing-xi HU Xi-cheng REN Fei-fei LIU Chao and GAN Jia-le |
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| Institution: | Graduate School of Ningxia Medical University, Yinchuan 750004, China,School of Chinese Materia Medica, Ningxia Medical University College of Traditional Chinese Medicine, Yinchuan 750004, China,Graduate School of Ningxia Medical University, Yinchuan 750004, China,Graduate School of Ningxia Medical University, Yinchuan 750004, China,Graduate School of Ningxia Medical University, Yinchuan 750004, China and Graduate School of Ningxia Medical University, Yinchuan 750004, China |
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| Abstract: | To investigate the intervention effect and its mechanism of treatment of cerebral ischemic stroke by Notoginseng Radix et Rhizoma saponins.To analyze and summarize the internal and oversea research in the related area about pharmacological effects and experimental references on treatment of cerebral ischemic stroke by Notoginseng Radix et Rhizoma saponins in recent years.The results suggest that Panax Notoginseng Saponins has obvious protective effects for the cerebral ischemic stroke by several different mechanisms.Notoginseng Radix et Rhizoma saponins and its effective components has obvious inhibiting inflammatory factor expression,toxicity of free-radical damage,anti-platelet aggregation and inhibition of apoptosis control gene,promoting peripheral nerve cell regeneration of ischemic stroke.There for it may become effective drug for the treatment of cerebral ischemic stroke and for its development and utilization are further provides a new thinking. |
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| Keywords: | Notoginseng Radix et Rhizoma saponins effective component ischemic stroke mechanism |
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