葛根芩连汤治疗小儿轮状病毒性肠炎疗效的Meta分析

目的:系统评价葛根芩连汤治疗小儿轮状病毒性肠炎(rotavirus enteritis)的有效性以及安全性。方法:计算机检索The Cochrane Library,Pubmed,Embase,中国期刊全文数据库(CNKI),中国生物医学文献数据库(CBM),中国科技期刊全文数据库(VIP)和万方数据库等中英文数据库,检索时间限定为建库至2015年6月13日,检索所有葛根芩连汤治疗小儿轮状病毒性肠炎的随机对照试验(randomized controlled trials,RCTs),并辅以手工检索相关核心期刊,追索纳入研究的参考文献。由两位评价者独立对符合纳入标准的研究进行严格质量评价和资料提取后,应用Rev Man 5.3软件进行Meta分析。结果:最终纳入10项研究,共1 092例患儿。Meta分析结果显示:与对照组相比,葛根芩连汤治疗小儿轮状病毒性肠炎能显著提高临床疗效OR=4.27,95%CI(2.76,6.62),P0.000 01],合并检验分析Z=6.49,两组差异具有统计学意义。发表性偏倚分析结果显示纳入研究可能存在发表偏倚。结论:葛根芩连汤治疗具有提高小儿轮状病毒性肠炎临床疗效的优势。鉴于本系统评价纳入的所有研究方法学和报告质量均不高,且样本量较少,故葛根芩连汤治疗小儿轮状病毒性肠炎的疗效以及安全性仍需要严格的、大样本、多中心的随机对照试验加以验证。

Meta-analysis of Gegen Qinlian Tang in Treating Infantile Rotavirus Enteritis

Objective: To systematically evaluate the safety and efficacy of Gegen Qinlian Tang in treating infantile rotavirus enteritis. Method: We searched Cochrane Library, Pubmed, Embase, CNKI, CBM, VIP and Wanfang Data through computer for data as at June 13, 2015.All of randomized controlled trials(RCTs) of Gegen Qinlian Tang in treating infantile rotavirus enteritis were searched, and research literatures included in the RCTs were also traced. Two researchers independently conducted the strict quality evaluation and data extraction for the included studies and made a Meta-analysis by using RevMan 5.3 software. Result: Totally 10 RCTs involving 1092 patients were included into the study. The Meta-analysis results showed that compared with the control group, Gegen Qinlian Tang can significantly improve the clinical effective rateOR=4.27, 95%CI(2.76,6.62), P<0.00001], and showed the combined test analysis result of Z=6.49, with statistically significant differencesin both groups. Conclusion: Gegen Qinlian Tang in treating infantile rotavirus enteritis can effectively improve the clinical effective rate. However, due to the low methodology and quality and small sample size of included RCTs in this study, more restrict high-quality multicenter RTCs are required to further verify the efficacy and safety of Gegen Qinlian Tang in treating infantile rotavirus enteritis.