| 与熏硫加工相关的白芷化学成分研究 |
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| 引用本文： | 蒋运斌,卢晓琳,杨枝中,马羚,马逾英.与熏硫加工相关的白芷化学成分研究[J].中国实验方剂学杂志,2013,19(22):74-78. |
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| 作者姓名： | 蒋运斌 卢晓琳 杨枝中 马羚 马逾英 |
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| 作者单位： | 成都中医药大学药学院, 中药资源系统研究与开发利用省部共建国家重点实验室培育基地, 成都 611137;四川农业大学农学院, 成都 611130;成都中医药大学药学院, 中药资源系统研究与开发利用省部共建国家重点实验室培育基地, 成都 611137;成都中医药大学药学院, 中药资源系统研究与开发利用省部共建国家重点实验室培育基地, 成都 611137;成都中医药大学药学院, 中药资源系统研究与开发利用省部共建国家重点实验室培育基地, 成都 611137 |
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| 基金项目： | 国家"十一五"科技支撑计划项目(2007BAI40B02) |
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| 摘 要： | 目的: 寻找与熏硫加工相关的白芷特征性化学成分。 方法: 利用正反相色谱、质谱、核磁共振,分离并鉴定化合物结构。采用高效液相色谱法分析。 结果: 分离鉴定了13个化合物,氧化前胡素(1),珊瑚菜内酯(2),花椒毒素(3),水合氧化前胡内酯(4),栓翅芹烯醇(5),异紫花前胡内酯(6),白当归素(7),佛手内酯(8),异虎耳草素(9),欧前胡素(10),异欧前胡素(11),白当归脑(12)和新白当归脑(13)。发现氧化前胡素、水合氧化前胡内酯、佛手内酯、白当归脑4个化合物在白芷熏硫前后指纹图谱中变化较为明显。 结论: 为白芷质量控制指标成分的选择提供新的依据。
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| 关 键 词： | 白芷 氧化前胡素 指纹图谱 药材质量 |
| 收稿时间： | 2013/6/26 0:00:00 |
Studies on the Chemical Constituents of Angelica dahurica Related to Sulfur Fumigated |
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| JIANG Yun-bin,LU Xiao-lin,YANG Zhi-zhong,MA Ling and MA Yu-ying.Studies on the Chemical Constituents of Angelica dahurica Related to Sulfur Fumigated[J].China Journal of Experimental Traditional Medical Formulae,2013,19(22):74-78. |
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| Authors: | JIANG Yun-bin LU Xiao-lin YANG Zhi-zhong MA Ling and MA Yu-ying |
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| Institution: | School of Pharmacy, Chengdu University of Traditional Chinese Medicine, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu 611137, China;Agronomy College, Sichuan Agricultural University, Chengdu 611130, China;School of Pharmacy, Chengdu University of Traditional Chinese Medicine, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu 611137, China;School of Pharmacy, Chengdu University of Traditional Chinese Medicine, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu 611137, China;School of Pharmacy, Chengdu University of Traditional Chinese Medicine, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu 611137, China |
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| Abstract: | Objective: To find the correlative characteristic components of Angelicae Dahuricae Radix which is related to sulfur fumigated. Method: Normal or reversed phase partition chromatography, mass spectrum and nuclear magnetic resonance spectroscopy were used for isolation and identification of compounds. Using high-performance liquid chromatography(HPLC) analysised. Result: Thirteen compounds were obtained and identified as oxypeucedanin(1), phellopterin(2), xanthotoxin(3), oxypeucedanin hydrate(4), pabulenol(5), marmesin(6), byakangelicin(7), bergapten(8), isopimpinellin(9), imperatorin(10), isoimperatorin(11), byakangelicol(12) and neobyakangelicol(13). Oxypeucedanin, oxypeucedanin hydrate,bergapten and byakangelicol were obviously changed in HPLC fringerprints after fumigated with sulfur. Conclusion: The quality control of Angelicae Dahuricae Radix provide new evidence for the selection of indicators. |
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| Keywords: | Angelicae Dahuricae Radix oxypeucedanin fingerprint quality of medicinal materials |
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