三虫补阳还五汤对急性脑梗死患者临床及血液流变学指标的影响

目的:观察中药三虫补阳还五汤对急性脑梗死患者临床及血液流变学指标的影响。方法:将入选的急性脑梗死患者100例随机分为治疗组52例和对照组48例,对照组用常规治疗方法(静脉滴注复方丹参注射液、依达拉奉注射液和奥扎格雷钠注射液,口服肠溶阿司匹林片、阿托伐他汀钙等);治疗组在常规治疗的基础上加三虫补阳还五汤口服。两组疗程均为30d。观察两组治疗前后临床疗效(神经功能缺损程度)及血液流变学指标(血黏度及平均血流速度)的变化。结果:治疗组总有效率显著高于对照组(P<0.05);治疗后两组的血黏度及神经功能缺损程度评分均较治疗前显著降低(P<0.05或P<0.01),两组血流速度均较治疗前显著升高(P<0.05或P<0.01),而治疗组指标改善显著优于对照组(P<0.05)。结论:三虫补阳还五汤能显著降低血黏度,显著增加脑血流量,治疗急性脑梗死安全有效。

Effect of Sanchong Buyang Huangwu Decoction on Acute CerebralInfarction and Its Influences on Hemorheological Parameters

Objective: To observe the effects of Sanchong Buyang Huanwu Decoction on acute cerebral infarction and its inflnences on hemorheological parameters. Method: One hundred patients with acute cerebral infarction were randomly divided into treatment group (52 cases) and control group(48 cases).The control group was treated with conventional treatment (intravenous infusion of Danshen injection,edaravone injection and ozagrel liquid,oral enteric-coated aspirin tablets,atorvastatin calcium).The treatment group took Sanchong Buyang Huanwu Decoction on the basis of conventional therapy. The 2 groups were continuously treated for 30 days.Changes in the clinical outcome (neurological impairment),and blood rheological parameters(blood viscosity and mean flow velocity) of two groups were observed before and after treatment. Result: After treatment for 30 days,the total effective rate in the treatment group was significantly higher than that in the control group (P<0.05).The blood viscosity and neurological deficit scores of two groups were significantly lower than that before treatment (P<0.05 or P<0.01).The blood viscosity and neurological deficit scores of the treatment group were significantly less than that of the control group (P<0.05). The blood flow velocity of two groups were significantly higher than that of before treatment (P<0.05 or P<0.01),The blood flow velocity of the treatment group were significantly higher than the control group (P<0.05). Conclusion: Sanchong Buyang Huanwu Decoction can significantly reduce blood viscosity,significantly increase cerebral blood flow,it is safe and effective in the treatment of acute cerebral infarction.