| 祛湿清肠方内服联合中药灌肠治疗轻中度活动期溃疡性结肠炎大肠湿热证临床观察 |
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| 引用本文： | 冯卓,韩昌鹏,李盈,王振宜,杨豪杰.祛湿清肠方内服联合中药灌肠治疗轻中度活动期溃疡性结肠炎大肠湿热证临床观察[J].中国实验方剂学杂志,2018,24(5):149-154. |
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| 作者姓名： | 冯卓 韩昌鹏 李盈 王振宜 杨豪杰 |
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| 作者单位： | 上海中医药大学 附属岳阳中西医结合医院, 上海 200437,上海中医药大学 附属岳阳中西医结合医院, 上海 200437,上海中医药大学 附属岳阳中西医结合医院, 上海 200437,上海中医药大学 附属岳阳中西医结合医院, 上海 200437,上海中医药大学 附属岳阳中西医结合医院, 上海 200437 |
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| 基金项目： | 国家自然基金青年基金项目（81403399，81603633）；上海市科委"科技创新行动计划"项目（16401971400） |
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| 摘 要： | 目的:观察祛湿清肠方内服联合中药灌肠治疗轻中度活动期溃疡性结肠炎(ulcerative colitis,UC)大肠湿热证的临床疗效及安全性,同时考察外周血细胞因子白细胞介素-17(interleukin-17,IL-17),白细胞介素-6(interleukin-6,IL-6),白细胞介素-10(interleukin-10,IL-10),转化生长因子-β1(transforming growth factor-beta 1,TGF-β1)的变化。方法:70例轻中度活动期UC大肠湿热证患者随机分为观察组和对照组,各35例。观察组给予中药口服,配合中药灌肠。对照组给予美沙拉嗪肠溶片口服。两组疗程均为3个月。比较两组患者Truelove与Witts分度,Sutherland DAI活动指数,中医证候改善情况,缓解率及外周血细胞因子IL-17,IL-6,IL-10,TGF-β1水平,并监测用药安全性。结果:治疗后观察组脓便血次数少于对照组(P0.05),红细胞沉降率(ESR)及C反应蛋白(CRP)水平显著低于对照组(P0.01),脉搏、体温及血红蛋白无差异。两组Sutherland DAI积分无差异,医师评估情况积分,观察组高于对照组(P0.05),排便次数、血便及内镜黏膜表现均无差异。观察组较对照组能更有效改善UC导致的临床症状(P0.01)。对照组缓解率51.43%(18/35),观察组缓解率74.29%(26/35),观察组优于对照组(P0.05)。观察组IL-17,IL-10水平显著低于对照组(P0.01),TGF-β1水平低于对照组(P0.05),IL-6水平无明显差异。观察组出现不良反应2例(恶心不适、肛周皮肤瘙痒),对照组出现不良反应3例(丙氨酸氨基转移酶升高至80 U·L-1以上)。结论:祛湿清肠方内服联合中药灌肠治疗轻中度活动期UC大肠湿热证有效、安全,而且对症状的改善优于美沙拉嗪。
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| 关 键 词： | 溃疡性结肠炎 白细胞介素 美沙拉嗪 转化生长因子-β1 |
| 收稿时间： | 2017/8/14 0:00:00 |
Clinical Observation of Qushi Qingchang Recipe Combined with Chinese Medicine for Treating Mild-to-moderate Ulcerative Colitis with Syndrome of Dampness-heat in Large Intestine |
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| FENG Zhuo,HAN Chang-peng,LI Ying,WANG Zhen-yi and YANG Hao-jie.Clinical Observation of Qushi Qingchang Recipe Combined with Chinese Medicine for Treating Mild-to-moderate Ulcerative Colitis with Syndrome of Dampness-heat in Large Intestine[J].China Journal of Experimental Traditional Medical Formulae,2018,24(5):149-154. |
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| Authors: | FENG Zhuo HAN Chang-peng LI Ying WANG Zhen-yi and YANG Hao-jie |
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| Institution: | 1. Yueyang Hospital of Integrative Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China,1. Yueyang Hospital of Integrative Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China,1. Yueyang Hospital of Integrative Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China,1. Yueyang Hospital of Integrative Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China and 1. Yueyang Hospital of Integrative Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China |
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