| 芪丹益肾降糖胶囊对糖尿病肾病大鼠的保护作用 |
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| 引用本文： | 宫彩霞,王旭璞,高艳峰,韩慈,王占平.芪丹益肾降糖胶囊对糖尿病肾病大鼠的保护作用[J].中国实验方剂学杂志,2011,17(4):140-143. |
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| 作者姓名： | 宫彩霞 王旭璞 高艳峰 韩慈 王占平 |
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| 作者单位： | 石家庄平安医院肾病科,石家庄,050012 |
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| 摘 要： | 目的:研究芪丹益肾降糖胶囊对糖尿病肾病(DN)大鼠的保护作用。方法:采用单侧肾脏切除并腹腔注射链脲佐菌素(STZ)的方法复制DN大鼠模型,分为假手术组、模型组、芪丹益肾降糖胶囊(QYJC)组,每组10只,ig给药,每天1次,12周后检测体重(BW)、空腹血糖(FBG)、尿素氮(BUN)、肌酐(SCr)、血清白蛋白(ALB)、总胆固醇(TC)、甘油三酯(TG)、尿蛋白排泄率(UAE);光镜观察肾组织形态学改变并对损害程度进行评分。结果:与模型组相比,QYJC能显著降低DN大鼠的FBG,BUN,TC,TG,UAE,降低肾小球硬化指数和肾小管间质纤维化指数。结论:芪丹益肾降糖胶囊对糖尿病肾病大鼠具有好的保护作用,可能与改善血脂代谢紊乱有关。
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| 关 键 词： | 糖尿病肾病 芪丹益肾降糖胶囊 肾功能 病理形态 |
| 收稿时间： | 2010/8/21 0:00:00 |
Renal Protective Effects of Qidan Yishen Jiangtang Capsule on Diabetic Nephropathy in Rats |
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| GONG Cai-xi,WANG Xu-pu,GAO Yan-feng,HAN Ci and WANG Zhan-ping.Renal Protective Effects of Qidan Yishen Jiangtang Capsule on Diabetic Nephropathy in Rats[J].China Journal of Experimental Traditional Medical Formulae,2011,17(4):140-143. |
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| Authors: | GONG Cai-xi WANG Xu-pu GAO Yan-feng HAN Ci and WANG Zhan-ping |
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| Institution: | (Shijiazhuang Ping’an Hospital,Shijiazhuang 050021,China) |
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| Abstract: | Objective:To study the renal protective effects of Qidan Yishen Jiangtang Capsule(QYJC)in diabetic nephropathy rats.Method:The DN rats model was established by one side nephrectomy and intraperitoneal injection of streptozotocin.Then rats were randomly divided into 3 groups: sham-operation group,model group,QYJC group,10 in each group.Rats were given the relevant drugs respectively for 12 weeks.Finally the levels of body weight(BW),fasting blood glucose(FBG),blood urea nitrogen(BUN),serum creatine(SCr),albu... |
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| Keywords: | diabetic nephropathy Qidan Yishen Jiangtang Capsule(QYJC) renal function pathomorphology |
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