不同配伍条件下麻杏石甘汤中钙离子溶出规律

目的:通过研究不同配伍条件下药液中钙离子(Ca2+)溶出量变化,探讨麻杏石甘汤的配伍规律。方法:采用电感耦合高频等离子体原子发射光谱(ICP-AES)法测定麻杏石甘汤中各单味药物、不同配伍条件下和不同浸泡和煎煮时间药液中Ca2+溶出量。结果:除杏仁外各单味药水煎药液中均含钙,其中石膏Ca2+溶出量最高,其次为麻黄,甘草Ca2+溶出量最低。石膏与其他药物配伍合煎,使药液中Ca2+溶出量降低。石膏单煎药液中Ca2+溶出量最高,其次为石膏、甘草配伍组,石膏、麻黄配伍组和石膏、杏仁配伍组,石膏、麻黄、甘草配伍组最低,复方配伍组药液中Ca2+溶出量仅高于石膏、麻黄、甘草配伍组。石膏和复方药液中Ca2+溶出量随浸泡时间延长而增加,随煎煮时间延长先升高后降低。但复方实测药组液中Ca2+溶出量随煎煮时间延长而降低的较为缓慢,石膏组和复方理论组药液中Ca2+溶出量下降迅速。结论:石膏与麻黄、杏仁、甘草2味药、3味药和复方配伍均可降低药液中Ca2+溶出量。增加浸泡时间可使药液中Ca2+溶出量增高,增加煎煮时间并不能使药液中Ca2+溶出量持续升高,反而在达到峰值后随煎煮时间延长而降低。石膏与麻黄、杏仁、甘草复方配伍意义在于使药液中Ca2+溶出量保持在一个较高且稳定的范围内。

Study on Calcium Ion Dissolution Regularity of Different Compatibility in Maxing Shigan Tang

Objective: To study the soluble calcium ion content of different compatibility of Maxing Shigan tang and to discuss the compatibility regularity of Maxing Shigan tang. Method: The ICP-AES was used to study the soluble calcium ion content of each single herb about their different compatibility and different soaking and boiling time in Maxing Shigan tang. Result: All of herbs except the Almond in Maxing Shigan tang contained calcium. Gypsum had the highest content of calcium, followed by Ephedra, Licoroce had the lowest. The calcium ion content was decreased when Gypsum compatible with other herbs. Gypsum decoction had the highest content of calcium, followed by Gypsum Ephedra, Gypsum Licoroce and Gypsum Almond groups; Gypsum Ephedra Licoroce group had the lowest content of calcium. The calcium ion content of Maxing Shigan tang group was higher than that of Gypsum Ephedra Licoroce group. The calcium ion content of gypsum and Maxing Shigan tang group was increased with extend time of soak, but was increased first and then decreased by extending the boiling time. Especially, in the group of Gypsum and Maxing Shigan tang theoretical value, the calcium ion content declined rapidly. Conclusion: The calcium ion content can be decreased when Gypsum compatible with other herbs and increased by extending the soaking time. The calcium ion content was increased first and then decreased when extending the boiling time. The Gypsum compatible with Ephedra, Licoroce and Almond will not increase the calcium ion content, but can keep it in a stable range.