地黄与熟地黄对糖尿病小鼠血糖血脂的影响

目的:比较地黄与熟地黄对链脲佐菌素(STZ)致糖尿病小鼠降血糖及血脂作用。方法:雄性C57小鼠ip链脲佐菌素(STZ)60 mg·kg-1建立糖尿病模型。地黄与熟地黄分别以6,4,2 g·kg-1剂量ig给药,1次/d,连续2周,分别观察其对糖尿病小鼠血糖血脂的影响。结果:地黄6 g·kg-1能降低链脲佐菌素致糖尿病小鼠的血糖及改善血脂水平,与模型组比较,P<0.01;地黄4 g·kg-1与熟地黄6 g·kg-1降血糖作用与模型组比较,P<0.05;地黄与熟地黄降糖尿病小鼠血糖及血脂的作用与剂量呈正相关。结论:地黄比熟地黄对链脲佐菌素致糖尿病小鼠降血糖及改善血脂水平更显著。

Effects of Rehmanniae Radix and Rehmanniae Radix Praeparata on Blood Glucose and Lipid in Diabetic Mice

Objective: To investigate the effects of Rehmanniae Radix and Rehmanniae Radix Praeparata on blood glucose and blood lipid in streptozocin-induced diabetic mice. Method: C57 male mice was administrated by intraperitoneal injection of STZ(60 mg ·kg^-1) to establish diabetes model. Fresh Rehmannia root of 6, 4, 2 g ·kg^-1 and prepared Rehmannia root of the same doses were ig administrated in grouped mice respectively once daily for a week. The effects on blood glucose and blood lipid in diabetic mice were observed accordingly. Result: Fresh Rehmannia root of 6 g ·kg^-1 could reduce blood glucose and improve blood lipid in the diabetic mice, compared with the mode group P<0.01.Fresh Rehmannia root of 4 g ·kg^-1 and prepared Rehmannia root of 6 g ·kg^-1 could reduce blood glucose, and compared with the mode group P<0.05.Fresh Rehmannia root and prepared Rehmannia root showed effects of reducing blood glucose and improving blood lipid in the diabetic mice with dose-effect manner. Conclusion: Fresh Rehmannia root is better for hypoglycemic effect and improving blood lipid in streptozotocin-induced diabetic mice than prepared Rehmannia root.