| 复方地黄对老年痴呆动物模型学习记忆能力的影响 |
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| 引用本文： | 杨斌.复方地黄对老年痴呆动物模型学习记忆能力的影响[J].中国实验方剂学杂志,2011,17(3):195-197. |
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| 作者姓名： | 杨斌 |
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| 作者单位： | 贵州省贵阳市第一人民医院药剂科,贵阳,550002 |
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| 摘 要： | 目的:探讨复方地黄对D-半乳糖致老年痴呆小鼠模型的学习记忆能力的影响及其机制。方法:sc10%D-半乳糖6周建立小鼠老年痴呆模型,然后用复方地黄3.37,1.75 g.kg-1 ig 4周,对照组和模型组给予等量生理盐水。用Y型迷宫检测小鼠的学习记忆能力,同时检测小鼠脑组织一氧化氮(NO)含量以及超氧化物歧化酶(SOD)的活性。结果:与空白组相比,模型组小鼠学习能力降低(p<0.01)。给予小鼠高剂量复方地黄后,小鼠上述变化明显改善,与模型组相比差异具有统计学意义(p<0.01)。结论:复方地黄可改善D-半乳糖致痴呆小鼠模型的学习记忆能力,其机制可能与复方地黄能使小鼠脑组织中NO含量降低和SOD活性升高有关。
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| 关 键 词： | 复方地黄 衰老小鼠 学习记忆 |
| 收稿时间： | 2010/12/6 0:00:00 |
Effects of Compound Rehmannia on Learning and Memory Abilities in Senile Dementia Mice Induced by D-galactose |
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| YANG Bin.Effects of Compound Rehmannia on Learning and Memory Abilities in Senile Dementia Mice Induced by D-galactose[J].China Journal of Experimental Traditional Medical Formulae,2011,17(3):195-197. |
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| Authors: | YANG Bin |
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| Institution: | The First People's Hospital of Guiyang, Guizhou 550002, China |
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| Abstract: | Objective:To study the effects of compound rehmannia on learning and memory abilities in senile dementia mice induced by D-galactose.Method:The senile dementia model mice were established by D-galactose hypodermic injection for 6 weeks and then given compound rehmannia in therapeutic group and the same volume of normal saline in the control.The learning and memory ability of all mice were test with Y-type maze,Nitric oxide(NO) and Superoxide dismutase(SOD) in brain were determined afterward.Result: Compared... |
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| Keywords: | D-galactose senile mice learning and memory |
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