| 健脾解毒方对幽门螺杆菌诱发胃癌血管新生的抑制研究 |
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| 引用本文： | 刘宁宁,王炎,周利红,赵成根,吴东辉,范忠泽,李琦.健脾解毒方对幽门螺杆菌诱发胃癌血管新生的抑制研究[J].中国实验方剂学杂志,2011,17(1):88-92,95. |
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| 作者姓名： | 刘宁宁 王炎 周利红 赵成根 吴东辉 范忠泽 李琦 |
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| 作者单位： | 上海中医药大学附属普陀医院,上海,200062 |
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| 基金项目： | 国家自然科学基金，上海市普陀区创新重大项目，上海市重点学科资助项目，上海市教委青年科研基金，上海市卫生局重点项目 |
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| 摘 要： | 目的:探讨健脾解毒方在幽门螺杆菌(Helicobacter priori,H.pylori)长期感染诱发C57BL/6小鼠胃癌过程中对微血管密度(microvessel density,MVD)和血管新生相关基因的调控作用,为其治疗H.priori感染相关胃病提供实验依据.方法:采用H.pylori标准株SS1 ig的...
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| 关 键 词： | 健脾解毒方 幽门螺杆菌 胃癌 血管新生 微血管密度 血管内皮生长因子 促血管生成素-2 促血管生成素-2受体 |
| 收稿时间： | 2010/7/19 0:00:00 |
Inhibition of Jianpi Jiedu Recipe on Angiogenesis in Helicobacter pylori-induced Gastric Cancer |
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| LIU Ning-ning,WANG Yan,ZHOU Li-hong,ZHAO Cheng-gen,WU Dong-hui,FAN Zhong-ze and LI Qi.Inhibition of Jianpi Jiedu Recipe on Angiogenesis in Helicobacter pylori-induced Gastric Cancer[J].China Journal of Experimental Traditional Medical Formulae,2011,17(1):88-92,95. |
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| Authors: | LIU Ning-ning WANG Yan ZHOU Li-hong ZHAO Cheng-gen WU Dong-hui FAN Zhong-ze and LI Qi |
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| Institution: | Putuo Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China;Putuo Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China;Putuo Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China;Putuo Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China;Putuo Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China;Putuo Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China;Putuo Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China |
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| Abstract: | Objective: To investigate the regulatory effects of Jianpi Jiedu Recipe on microvessel density(MVD) and angiogenesis-related genes in the course of Helicobacter pylori(H.pylori) long-term infection induced gastric adenocarcinoma of C57BL /6 mice,and provide experimental basis for Jianpi Jiedu Recioe treatment of the H.pylori-related gastropathy.Method: C57BL /6 mouse gastric cancer model induced by H.pylori infected was established by gavage with H.pylori standard strain SS1,and mice were divided into 4 gro... |
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| Keywords: | Jianpi Jiedu Recipe Helicobacter pylori gastric cancer angiogenesis microvessel density vascular endothelial growth factor angiopoietin-2 Tie-2 |
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