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大黄黄连泻心汤、理中丸对幽门结扎型及醋酸涂抹型胃溃疡 寒、热证大鼠模型的药效学比较研究
引用本文:柴剑波,李冀,毕珺辉,于海,赵伟国,蒋蕾,谢田.大黄黄连泻心汤、理中丸对幽门结扎型及醋酸涂抹型胃溃疡 寒、热证大鼠模型的药效学比较研究[J].中国实验方剂学杂志,2011,17(5):134-136.
作者姓名:柴剑波  李冀  毕珺辉  于海  赵伟国  蒋蕾  谢田
作者单位:黑龙江中医药大学,哈尔滨,150040
基金项目:"十一五"国家科技支撑计划项目
摘    要:目的:探讨寒、热方剂对幽门结扎型、醋酸涂抹型胃溃疡寒热证模型大鼠溃疡指数的影响,从药效学角度验证模型的可行性,并阐明其方证相应的客观规律。方法:采用"寒、热因素"分别结合幽门结扎、醋酸涂抹法,建立大鼠胃溃疡寒、热证模型,分别予大黄黄连泻心汤(1.8 g.kg-1)和理中丸(3.6 g.kg-1)ig,连续4 d测定其溃疡指数。结果:病证结合模型组溃疡指数皆明显高于单纯病模型组(P<0.01)。大黄黄连泻心汤治疗组及理中丸治疗组与病证结合模型组比较溃疡指数显著下降(P<0.05或P<0.01)。且寒性方剂大黄黄连泻心汤对于热模型的治疗作用明显优于热性方剂理中丸;热性方剂理中丸对于寒模型的治疗作用明显优于寒性方剂大黄黄连泻心汤(P<0.05)。结论:大黄黄连泻心汤对热模型胃黏膜损伤有显著的防治作用;理中丸对寒模型发挥了明显的防治作用,有效降低其溃疡指数,体现了一定的方证相应规律。

关 键 词:幽门结扎  醋酸  胃溃疡  寒热证  药效学
收稿时间:2010/9/28 0:00:00

Comparative Study of Dahuang Huanglian Xiexin Decoction,Lizhong Pill on Pharmacodynamics for Gastric Ulcer with Cold or Heat Syndrome Induced by Pylorus Deligation or Smearing Acetic Acid in Rats
CHAI Jian-bo,LI Ji,BI Jun-hui,YU Hai,ZHAO Wei-guo,JIANG Lei and XIE Tian.Comparative Study of Dahuang Huanglian Xiexin Decoction,Lizhong Pill on Pharmacodynamics for Gastric Ulcer with Cold or Heat Syndrome Induced by Pylorus Deligation or Smearing Acetic Acid in Rats[J].China Journal of Experimental Traditional Medical Formulae,2011,17(5):134-136.
Authors:CHAI Jian-bo  LI Ji  BI Jun-hui  YU Hai  ZHAO Wei-guo  JIANG Lei and XIE Tian
Institution:Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,China;Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,China;Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,China;Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,China;Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,China;Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,China;Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,China
Abstract:
Keywords:pylorus deligation  acetic acid  gastric ulcer  cold or heat syndrome  pharmacodynamics
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