中药致药源性肝损伤的氧化应激机制研究进展

由于各种新药的广泛应用以及联合用药的增多,药源性肝损伤(DILI)已成为医疗卫生工作者、制药工业和药品管理部门共同面对的重要问题。大量研究表明,氧化应激对中药致DILI的产生起重要作用,而具有抗氧化作用的中药通过对抗氧化应激而对DILI有一定的拮抗作用。作者主要对中药致DILI的氧化应激机制以及常见抗氧化中药对DILI的拮抗的研究进展进行综述和分析。

Research Progress in Mechanism Based on Oxidative Stress of Liver Injury Induced by Chinese Medicine

Due to wide applications of various new drugs and more and more combination therapies,drug-induced liver injury(DILI)has become a major and common problem for workers engaged in health care,pharmaceutical industries and drug administration departments.Many studies reported that oxidative stress(OS)could play an important role in the liver injury induced by Chinese medicine.In recent years,researchers have found that Chinese medicines which have antioxidant action can inhibit DILI by preventing against OS.The present study mainly reviewed on the OS-based mechanism of DILI and the protection against it by the common antioxidant Chinese medicine.