| 安胃汤对慢性萎缩性胃炎模型大鼠 肠三叶因子基因表达的影响 |
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| 引用本文： | 韦维,林寿宁,朱永苹.安胃汤对慢性萎缩性胃炎模型大鼠 肠三叶因子基因表达的影响[J].中国实验方剂学杂志,2011,17(3):159-162. |
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| 作者姓名： | 韦维 林寿宁 朱永苹 |
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| 作者单位： | 1. 广西中医学院,南宁,530001
2. 广西中医学院瑞康医院消化内科,南宁,530011 |
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| 摘 要： | 目的:探讨安胃汤对实验性慢性萎缩性胃炎大鼠模型的肠三叶因子(intestinal trefoil factor,TFF3)基因表达的影响。方法:采用甲基硝基亚硝基胍(N-methyl-N′-nitro-N-nitroso-guani dine,MNNG)慢性萎缩性胃炎(chronic atrophic gastritis,CAG)大鼠模型,36只清洁级健康雄性Wistar大鼠随机分为病理模型组、安胃汤组、胃复春组共3组。实时荧光定量PCR方法观察安胃汤对实验性慢性萎缩性胃炎大鼠模型胃黏膜TFF3 mRNA表达的影响,对后者进行图像分析及统计学处理。结果:病理模型组,安胃汤组和胃复春组TFF3 mRNA/β-actin值分别为(0.95±0.23),(0.43±0.04),(0.64±0.04),与病理模型组比较,安胃汤组和胃复春组均显著降低TFF3 mRNA/β-actin值(P<0.01);安胃汤组作用优于胃复春组(P<0.05)。结论:安胃汤可能通过降低胃黏膜TFF3 mRNA表达而起到治疗CAG作用。
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| 关 键 词： | 安胃汤 慢性萎缩性胃炎 肠三叶因子 实验研究 |
| 收稿时间： | 8/7/2010 12:00:00 AM |
Effect of Anwei Decoction on Intestinal Trefoil Factor mRNA in Chronic Atrophic Gastritis Rats |
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| WEI Wei,LIN Shou-ning and ZHU Yong-ping.Effect of Anwei Decoction on Intestinal Trefoil Factor mRNA in Chronic Atrophic Gastritis Rats[J].China Journal of Experimental Traditional Medical Formulae,2011,17(3):159-162. |
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| Authors: | WEI Wei LIN Shou-ning and ZHU Yong-ping |
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| Institution: | Guangxi Traditional Chinese Medicine University, Nanning 530011, China;Department of Gastroenterology, Ruikang Affiliated Hospital of Guangxi Chinese Medicine University, Nanning 530011, China;Department of Gastroenterology, Ruikang Affiliated Hospital of Guangxi Chinese Medicine University, Nanning 530011, China |
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| Abstract: | |
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| Keywords: | Anwei decoction atrophic gastritis intestinal trefoil factor experimental research |
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