精葚果颗粒对2型糖尿病大鼠降血糖作用的研究

目的:观察精葚果颗粒对链脲佐菌素(STZ)所致2型糖尿病大鼠的降糖作用.方法:采用高脂饲料诱导加腹腔注射STZ的方法建立2型糖尿病大鼠模型.按血糖随机分为模型对照组、精葚果颗粒低(L,1.0g·kg-1),高剂量组(H,3.0g·kg-1),盐酸二甲双胍组(0.3 g·kg-1).各组均ig给药14d.观察精葚果颗粒对2型糖尿病大鼠体重、空腹血糖(FBG)、总胆固醇(TC)及甘油三酯(TG)、高密度脂蛋白( HDL-C)、血清胰岛素(Ins)的影响.结果:精葚果颗粒低、高剂量组均能明显降低2型糖尿病大鼠的FBG,给药14 d后较模型对照组FBG明显下降(P ＜0.05)；TC及TG均显著降低(P＜0.05) HDL-C及Ins的含量升高(P＜0.05).精葚果高剂量组的降糖效果优于低剂量组(P＜0.05).结论:精葚果颗粒可降低2型糖尿病大鼠的血糖、血脂,其作用机制可能与增加胰岛素敏感性、改善脂质代谢有关.

Experimental Study on Hypoglycemic Effect of Jingshenguo Granule in Type 2 Diabetic Rats

Objective:To observe the hypoglycemic effect of Jingshenguo granule on type 2 diabetic rats caused by streptozotocin(STZ).Method: Type 2 diabetic rat model was established by diet of high fat combined with intraperitoneal injection of STZ.And then according to their blood glucose levels,the models were randomly divided into four groups which were model control group,Jingshenguo granule low dosage group(1.0 g·kg-1),Jingshenguo granule high dosage group(3.0 g·kg-1),and metformin hydrochloride group(0.3 g·kg-1).The treatment in each group was administrated ig for fourteen days.The influence from Jingshenguo granule was investigated on type 2 diabetic rats regarding weight,fast blood glucose,total cholesterol,triglyceride,high-density lipoprotein,serum insulin.Result: Low and high doses of Jingshenguo granule could significantly lower(FBG),(TC) and(TG)(P<0.05),and could increase(HDL-C) and(Ins) content(P<0.05) in type 2 diabetic rats after fourteen days’ medical administration compared with that of model control group(P<0.05).And Jingshenguo granule high dose group had better hypoglycemic effect than that of low dose group(P<0.05).Conclusion: Jingshenguo granule can reduce blood glucose and blood lipid in type 2 diabetic rats,which may be related to the increase of insulin sensitivity and regulation of lipids metabolism.