| 红花黄色素对小鼠脑缺血再灌注损伤的保护作用 |
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| 引用本文： | 迪丽努尔·沙比托夫,朱毅忠,买尔旦·米吉提,陈希元.红花黄色素对小鼠脑缺血再灌注损伤的保护作用[J].中国中医药信息杂志,2006,13(2):26-27. |
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| 作者姓名： | 迪丽努尔·沙比托夫 朱毅忠 买尔旦·米吉提 陈希元 |
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| 作者单位： | 1. 新疆维吾尔自治区药品检验所,新疆,乌鲁木齐,830002
2. 新疆医科大学药学院,新疆,乌鲁木齐,830054 |
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| 摘 要： | 目的观察红花黄色素对小鼠脑缺血及再灌注损伤的影响。方法采用断颅、静脉注射饱和氯化镁溶液的方法造成小鼠脑缺血模型,观察红花黄色素对小鼠脑缺血后存活时间的影响。采用结扎小鼠双侧颈总动脉的方法造成小鼠脑缺血再灌注模型,观察红花黄色素对脑组织超氧化物歧化酶(SOD)活性及丙二醛(MDA)含量的影响。结果小鼠静脉注射红花黄色素,能明显增加断颅后的张口次数及心脏骤停后的张口呼吸时间;显著延长常压耐缺氧时间;显著提高小鼠脑缺血再灌注后脑内SOD活性,明显降低脑内MDA含量。结论红花黄色素对小鼠脑缺血缺氧具有一定的保护作用。
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| 关 键 词： | 红花黄色素 脑缺血 再灌注损伤 超氧化物歧化酶 丙二醛 |
| 文章编号： | 1005-5304（2006）02-0026-02 |
| 收稿时间： | 2005-03-23 |
| 修稿时间： | 2005年3月23日 |
Protective Effects of Safflow Yellow on Cerebral Ischemia and Reperfusion Injury in Mice |
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| Dilinur SHABITOF,ZHU Yi-zhong,Mardan MIJIT,et al.Protective Effects of Safflow Yellow on Cerebral Ischemia and Reperfusion Injury in Mice[J].Chinese Journal of Information on Traditional Chinese Medicine,2006,13(2):26-27. |
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| Authors: | Dilinur SHABITOF ZHU Yi-zhong Mardan MIJIT |
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| Institution: | Dilinur SHABITOF1,ZHU Yi-zhong1,Mardan MIJIT2,et al |
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| Abstract: | Objective To observe the effects of safflow yellow (SY) on cerebral ischemia and reperfusion injure in mice. Method By using decapitating, intraveneous injection of saturated MgCl2, the effects of SY on survival time in mice were studied. With the model of cerebral ischemia for 20 min and reperfusion for 10 min, the superoxide dimutases (SOD) active and Malondialdehyde (MDA) content in brain tissue were tested. Result Introvenous injection of SY before ischemia can prolonged the survival time significantly. Meanwhile, SY was found to increase the activity of SOD and reduce the content of MDA after cerebral ischemia and reperfusion in mice. Conclusion SY has a protective effects on brain ischemia. |
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| Keywords: | safflow yellow cerebral ischemia reperfusion injury SOD MDA |
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