慢性阻塞性肺病肺气虚证和肺阴虚证患者细胞因子变化的研究

目的研究慢性阻塞性肺病（COPD）肺气虚证和肺阴虚证患者细胞因子的水平及差异。方法分别对COPD肺气虚证患者30例、COPD肺阴虚证患者30例和健康对照者30例血清白细胞介素（IL）-8、IL-1β、肿瘤坏死因子α（TNF—α）的水平进行检测。结果COPD肺气虚证和肺阴虚证患者血清IL-8、IL-1β、TNF-α的水平均较健康对照者显著增高（P〈0．01），且肺阴虚组高于肺气虚组，组间比较差异有统计学意义（P〈0．05）。结论COPD肺气虚证和肺阴虚证患者存在高水平的细胞因子，肺阴虚证患者更明显。

Study on Changes of Cytokine in COPD Patients with Lung Qi Deficiency Syndrome and Lung Yin Deficiency Syndrome

Objective To study the level and difference of cytokine in COPE） patients with lung qi deficiency syndrome and lung yin deficiency syndrome. Methods The level of IL-8, IL-1β and TNF-α in COPD patients were detected respectively. There were 30 cases with lung qi deficiency syndrome and 30 cases with lung yin deficiency syndrome, meanwhile, thirty healthy people were selected as the control group. Results The cytokine level of lung qi deficiency syndrome and lung yin deficiency syndrome was significant higher than that of the health people （P〈0.01）, and that of the lung yin deficiency syndrome was higher than that of the lung qi deficiency syndrome （P〈0.05）. Conclusions The patients of COPD with lung qi deficiency syndrome and lung yin deficiency syndrome had high level of cytokine, and that of the patients with lung yin deficiency syndrome was obvious.