| 眼针疗法对大鼠脑缺血再灌注后海马组织脑源性神经营养因子表达的影响 |
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| 引用本文： | 高原,王哲,王莹,王守岩,马贤德,关洪全,王德山.眼针疗法对大鼠脑缺血再灌注后海马组织脑源性神经营养因子表达的影响[J].中国中医药信息杂志,2011,18(10):38-39,112. |
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| 作者姓名： | 高原 王哲 王莹 王守岩 马贤德 关洪全 王德山 |
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| 作者单位： | 辽宁中医药大学,辽宁沈阳,110847 |
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| 基金项目： | 国家重点基础研究发展计划 |
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| 摘 要： | 目的观察眼针疗法对大鼠脑缺血再灌注后海马组织脑源性神经营养因子（BDNF）表达的影响,探讨脑保护作用机制。方法线栓法制备SD大鼠大脑中动脉梗死再灌注模型。将SD大鼠随机分为正常对照组、假手术组、模型组、眼针组4组。于再灌注72 h后采用ZeaLonga评分法进行大鼠神经功能缺损评分,采用实时定量PCR方法检测缺血海马组织BDNF mRNA的表达,采用蛋白免疫印迹法检测缺血海马组织BDNF的表达。结果缺血再灌注72 h后,眼针组大鼠神经功能缺损评分显著低于模型组（P〈0.05）,眼针组大鼠海马组织BDNF mRNA的表达和蛋白的表达较模型组均明显减少（P〈0.01）。结论眼针疗法能提高大鼠缺血再灌注后海马组织BDNF表达水平,通过促进神经元的修复发挥脑保护的作用。
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| 关 键 词： | 缺血再灌注 脑源性神经营养因子 眼针疗法 海马 大鼠 |
Effect of Eye Acupuncture on Brain-deprived Neurotrophic Factor Expression in Rat Hippocampus with Ischemia-reperfusion Injury |
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| GAO Yuan,WANG Zhe,WANG Ying,WANG Shou-yan,MA Xian-de,GUAN Hong-quan,WANG De-shan.Effect of Eye Acupuncture on Brain-deprived Neurotrophic Factor Expression in Rat Hippocampus with Ischemia-reperfusion Injury[J].Chinese Journal of Information on Traditional Chinese Medicine,2011,18(10):38-39,112. |
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| Authors: | GAO Yuan WANG Zhe WANG Ying WANG Shou-yan MA Xian-de GUAN Hong-quan WANG De-shan |
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| Institution: | GAO Yuan,WANG Zhe,WANG Ying,WANG Shou-yan,MA Xian-de,GUAN Hong-quan,WANG De-shan(Liaoning University of TCM,Shenyang 110847,China) |
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| Abstract: | Objective To investigate the effects of eye acupuncture on brain-derived neurotrophic factor expression(BDNF),and study its mechnism of cerebral protection from ischemia-reperfusion injury.Methods MCAO model rats established by suture method were randomly divided into the control group,the sham operation group,the model group and the eye-acupuncture group.After reperfusion 72 h,the neurophysical behaviours were accessed by ZeaLonga neurophysical impairment marks.The expression of ischemic hippocampus BDNF m... |
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| Keywords: | ischemia-reperfusion injury brain-derived neurotrophic factor eye acupuncture hippocampus rats |
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