中药治疗儿童咳嗽变异性哮喘系统评价/Meta分析再评价

目的 再评价中药治疗儿童咳嗽变异性哮喘(CVA)系统评价/Meta分析的文献报告质量、方法学质量和证据质量.方法 计算机检索中国学术期刊数据库(万方数据)、中国生物医学文献数据库(CBM)、中国知识资源总库(CNKI)、中文科技期刊数据库(维普网)、Embase、PubMed、Cochrane Library建库至20...

Reevaluation of Meta-analysis and Systematic Evaluation of TCM in Treating Children with Cough Variant Asthma

Objective To reevaluate the quality of literature report,methodology and evidence for systematic evaluation and Meta-analysis of TCM for treatment of cough variant asthma(CVA)in children.Methods Systematic evaluation and Meta-analysis of Wanfang Data,CBM,CNKI,VIP,Embase,PubMed and Cochrane Library were retrieved by computer.The retrieval time was from the establishment of the database to October 2020.Two researchers independently conducted literature screening and data extraction,and used PRISMA statement,AMSTAR 2 tool and GRADE system to evaluate the quality of the literature.Results Totally 12 studies were included.PRISMA statement evaluation showed that 12 studies reported good quality,but all were lack of protocol registration reports.According to the AMSTAR 2 tool evaluation,no preliminary design scheme was provided in the 12 studies,no inclusion and exclusion list and reasons were provided in 8 studies,no publication bias analysis was conducted in 5 studies,and no potential conflicts of interest were reported in 4 studies.The GRADE system analysis showed that the quality of evidence for 30 outcome indicators was low or very low,with limitations,publication bias,inaccuracy,and inconsistencies as the main downgrades,and no escalation factors were found.Conclusion At present,TCM treatment of CVA in children is supported by low quality evidence-based medicine evidence,but the methodological quality of systematic evaluation and Meta-analysis is poor,the quality of evidence is low,the standardization is poor,and the quality of the original literature is poor.Therefore,the top-level trial scheme design of original literature needs to be strengthened.