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左归丸对卵巢切除所致骨质疏松大鼠骨钙素和降钙素含量的影响
引用本文:鞠大宏,吴萍,贾红伟,余明哲.左归丸对卵巢切除所致骨质疏松大鼠骨钙素和降钙素含量的影响[J].中国中医药信息杂志,2003,10(1):16-17.
作者姓名:鞠大宏  吴萍  贾红伟  余明哲
作者单位:1. 中国中医研究院基础理论研究所,北京,100700
2. 北京中医药大学
摘    要:目的:探讨左归丸防治骨质疏松症的机理。方法:以卵巢切除所致的骨质疏松大鼠为模型。采用骨组织形态计量学方法测定胫骨骨小梁体积百分比(TBV%),骨小梁吸收表面百分比(TRS%)和骨小梁形成表面百分比(TFS%),采用放射免疫分析法测定外周血清中雌二醇(E2),骨钙素(BGP)和降钙素(CT)的含量。结果:左归丸能使胫骨TBV%显著增高,使TRS%和TFS%显著降低,大鼠切除卵巢后,在E2含量大幅度降低的同时。BGP含量明显增加,CT含量明显降低,左归丸对E2含量无显著影响,但能使CT含量增加。使BGP含量降低。结论:左归丸能使CT含量增加是其防治骨质疏松症的机理之一。

关 键 词:左归丸  骨质疏松  骨钙素  降钙素  中医药疗法
修稿时间:2002年6月27日

Effect of Zuogui Pill on the Content of Bone Gla-containing Protein and Calcitonim in Ovariectomy-induced Osteoporosis Rats
Ju Dahong,Wu Ping,Jia Hongwei,et al.Effect of Zuogui Pill on the Content of Bone Gla-containing Protein and Calcitonim in Ovariectomy-induced Osteoporosis Rats[J].Chinese Journal of Information on Traditional Chinese Medicine,2003,10(1):16-17.
Authors:Ju Dahong  Wu Ping  Jia Hongwei  
Abstract:Objective: To study the mechanism of Zuogui pill of preventing and treating osteoporosis. Methods: The ovariectomy-induced osteoporosis rat model was adopted. TBV%, TRS% and TFS% in tibia were measured by bone histomorphometry. The content of bone Gla-containing protein (BGP) and Calcitonim (CT) in blood serum were detected with the radioimmunoassay (RIA). Results: Zuogui pill can increased TBV% and decreased TRS%, TFS% markedly. After rats have been spaied, the content of BGP heightened markedly, and the content of CT reduced markedly while the content of E2 reduced markedly. Zuogui pill had no effect on the content of E2, but it can increased CT and decreased BGP markedly. Conclusion: Zuogui pill increasing the content of CT was one of mechanisms of its preventing and treating osteoprosis.
Keywords:Zuogui pill  osteoporosis  bone gla-containing protein (BGP)  calcitonim (CT)  
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