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参芪补肺汤对肺气虚证慢性阻塞性肺疾病大鼠气道重构中MMP-9和TIMP-1蛋白表达的影响
引用本文:张葵,张樱,陈翌江,芦莉.参芪补肺汤对肺气虚证慢性阻塞性肺疾病大鼠气道重构中MMP-9和TIMP-1蛋白表达的影响[J].中国中医药信息杂志,2008,15(8).
作者姓名:张葵  张樱  陈翌江  芦莉
作者单位:1. 贵阳中医学院第一附属医院,贵州贵阳,550001
2. 贵阳市妇幼保健院,贵州贵阳,550002
摘    要:目的 观察参芪补肺汤对肺气虚证慢性阻塞性肺疾病(COPD)大鼠气道重构中基质金属蛋白酶(MMPs)及其组织型金属蛋白酶抑制物(TIMPs)蛋白表达的影响.方法 用烟、二氧化硫定量熏吸并复合木瓜蛋白酶雾化吸入法,建立肺气虚证COPD大鼠模型.60只雄性Wistar大鼠随机分为正常组,模型组、补低组、补中组、补高组,激素组.半定量图像分析法测量小气道管壁和平滑肌层厚度;免疫组化法检测支气管肺组织MMP-9、TIMP-1的表达.结果 与正常组比较,模型组MMP-9和TIMP-1蛋白在支气管肺组织中高表达(P<0.01),小气道管壁及平滑肌层均显著增厚(P<0.01).治疗后,与模型组比较,补高组、补中组和激素组MMP-9蛋白表达显著减少(P<0.01),激素组优于中药组(P<0.01);补高组、补中组TIMP-1蛋白表达均显著减少(P<0.01);补高组管壁及平滑肌层厚度显著降低(P<0.05).结论 参芪补肺汤可抑制支气管肺组织MMP-9、TIMP-1蛋白表达,干预肺气虚证COPD大鼠气道重构.

关 键 词:参芪补肺汤  慢性阻塞性肺疾病  肺气虚证  气道重构  基质金属蛋白酶  大鼠

Effects of Shenqi Bufeitang on Expessions of MMP-9 and TIMP-1 in Airway Remodeling of COPD Rat Model with Lung-Qi Deficiency Syndrome
ZHANG Kui,ZHANG Ying,CHEN Yi-jiang,et al.Effects of Shenqi Bufeitang on Expessions of MMP-9 and TIMP-1 in Airway Remodeling of COPD Rat Model with Lung-Qi Deficiency Syndrome[J].Chinese Journal of Information on Traditional Chinese Medicine,2008,15(8).
Authors:ZHANG Kui  ZHANG Ying  CHEN Yi-jiang  
Institution:ZHANG Kui1,ZHANG Ying2,CHEN Yi-jiang1,et al (1.The First Affiliated Hospital of Guiyang College of TCM,Guiyang 550001,China,2.The Materuity , Child Health Hospital of Guiyang,Guiyang 550002,China)
Abstract:Objective To observe the effects of Shenqi Bufeitang on expessions of metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in the airway remodeling of COPD rat model with lung-Qi deficiency syndrome. Methods Quantitative stimulation with tobacco,SO2 and papin was made to establish COPD rat model with lung-Qi deficiency syndrome. Sixty male rats were randomly divided into normal group (N),model group (M),low dose treatment group (LT),medium dose treatment group (MT),high dose trea...
Keywords:Shenqi Bufeitang  chronic obstructive pulmonary disease  lung-Qi deficiency syndrome  airway remodeling  metalloproteinase  rat  
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