| 盐酸萘替芬离体透皮吸收的研究 |
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| 引用本文： | 刘星,乔建忠,耿建兵,袁淑兰.盐酸萘替芬离体透皮吸收的研究[J].中国药学杂志,1999,34(6):388-391. |
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| 作者姓名： | 刘星 乔建忠 耿建兵 袁淑兰 |
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| 作者单位： | 北京军事医学科学院毒物药物研究所 |
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| 摘 要： | 目的:研究盐酸萘替芬软膏制剂对离体人皮、豚鼠皮透皮吸收率?方法:采用静态渗透室装置,皮片涂药后不同时间采样,样品中盐酸萘替芬浓度采用高效液相色谱方法测定?结果:盐酸萘替芬经离体人皮、豚鼠皮的渗透率均随着时间的增加而缓慢地增加,36h后,盐酸萘替芬经离体人皮及豚鼠皮的渗透率分别为3.489%和0.726%?结论:盐酸萘替芬软膏人及豚鼠局部皮肤给药后,可能大部分滞留在皮肤表面上,很少透皮吸收?
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| 关 键 词： | 盐酸萘替芬 透皮吸收 离体 |
| 收稿时间： | 1998-04-30; |
Study on the permeability of naftifine hydrochloride in vitro |
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| Liu Xing.Study on the permeability of naftifine hydrochloride in vitro[J].Chinese Pharmaceutical Journal,1999,34(6):388-391. |
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| Authors: | Liu Xing |
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| Institution: | (Liu X)，Oiao Jianzhong(Qiao JZ)，Geng Jianbing(Geng JB)，et a |
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| Abstract: | OBJECTIVE: To study the permeability of naftifine hydrochloride ointment through skins of guinea pigs and human beings in vitro. METHODS: A static glass diffusion cell system was used.Samples were collected at different time after the drug was applied.The concentration of naftifine hydrochloride in the samples was measured by HPLC. RESULTS: It showed that the permeability of naftifine hydrochloride through skins of guineap pigs and human beings gradually increased in a slowly manner within the experimental time.The permeability of naftifine hydrochloride through the skins of guinea pigs and human beings at 36hr postapplication were 3.489% and 0.726% respectively. CONCLUSION: Large amount of naftifine hydrochloride may remain in the surface of the skins,and a little may be absorbed through skins of guinea pigs and human beings in vitro after the drug is applied. |
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| Keywords: | naftifine hydrochloride percutaneous absorption in vitro |
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