血中甲硝唑浓度与降血脂效果的关系

 目的：证实甲硝唑的降脂作用并研究血药浓度与降脂效果的关系。方法：23例高脂血症患者分为两组，po甲硝唑：A组13例，600mgtid；B组10例，400mgtid。两周后测定其血中最低稳态药物浓度（c^ss_min）及胆固醇（CH）、三酰甘油（TG）值。结果：A、B两组平均c^ss_min分别为（13．82±4．12）mg·L^－1和（10．20±2．59）mg·L^－1。17例降TG有效和6例无效的患者平均csmin分别为（13．27±3．92）mg·L^－1和（9．35±2．20）mg·L^－1（P＜0．05）；15例降CH有效和8例无效的患者c^ss_min分别为（14．08±3．59）mg·L^－1和（8．80±1．29）mg·L^－1（P＜0．001）。将23例患者的TG和CH降低率分别与c^ss_min作线性回归，相关系数r分别为0．549和0．675，表明血脂降低程度与c^ss_min有高度相关性。结论：血中甲硝唑浓度与用药剂量关系显著且与降脂效果呈正相关关系。

The relationship between the concentration of metronidazole in serum and its curative effect for hyperlipidemia

OBJECTIVE: To verify the antilipemic effect of metronidazole and the relationship of its concentration in serum to its curative effect for hyperlipidemia. METHODS: Twenty-three patients were divided into 2 groups and given oral metronidazole three times a day: group A, 13 patients, 1 800 mg per day, and group B, 10 patients, 1 200 mg per day. The cholesterol (CH), triglyceride (TG) levels in blood and the minimum concentration in stead state (c^ss_min) of metronidazole in serum were determined in two weeks. RESULTS: The average c^ss_min of the group A and B was (13.82±4.12)mg·L^-1 and (10.20±2.59)mg·L^-1 respectively (P<0.05). The average c^ss_min of 17 patients, that was effective in lowering TG and 6 patients, that was ineffective was (13.27±3.92)mg·L^-1 and (9.35±2.20)mg·L^-1 respectively (P<0.05). The average c^ss_min of 15 patients effective in lowering CH and 8 ineffective patients was (14.08±3.59)mg·L^-1 and (8.80±1.29)mg·L^-1 (P<0.001). The linear regression analysis indicated that the decreasing rates of TG and CH of 23 patients were both highly correlated with their c^ss_min. CONCLUSIONS: The concentration of metronidazole in serum is correlated closely with its dosage and has a significant positive correlation with its antilipemic effect.