西咪替丁对麦滋林－S中水溶性薁在人体内药物动力学的影响

 建立了高效液相色谱法测定人体血浆中水溶性芝浓度的方法，并测定了７名健康史试者ｐＯ麦滋林－Ｓ及麦滋林－Ｓ和西咪替丁后，其水溶性的血药浓度和药物动力学参数，生物半衰期Ｔ＿（１／２）分别为２．９±１．４１和２．６±０．７４ｈ，达峰时间分别为２．８１±０．７６５和３．２６±０．６１１ｈ，血药浓度曲线下面积ＡＵＣ＿（０～∞）１７．１±４．４７和１８．９±３．５１（μｇ·ｈ）／ｍｌ。经数理统计学分析，两组药物动力学参数无显著性差异（Ｐ＞０．０５）。结果表明：西咪替丁对麦滋林－Ｓ粒中水溶性芝的药物动力学没有影响。

Cimetidine effect on azulene in Marzulene-S pharmacokinetics in healthy volunteers

A high performance liquid chromatographic method was used for separation and de-termination of Marzulene-S in human plasma. Comparison of the pharmacokinetic behaviors be-tween separated and combined administration Marzulene-S and cimetidine with the above methodwas carried out in seven healthy volunteers, Individual subject concentration-time was analysedand the results indicated that the data of azulene fitted in a one-compartment model. The metabo-lite half-time was 2.9±1. 41 h and 2.6±0. 74 h. The areas under the plasma concentration-timecurves(AUC)of azulene were 17. 11±4. 47(μg·h)/ml and 18. 95±3. 51(μg·h)/ml,and thetime of peak was 2. 81±0. 76 h and 3.26±0. 611 h. No significant difference was found betweenseparated and combined administration. Marzulenes-S of pharmacokinetic parameters were ana-lyzed statistically. The results showed that cimetidine didn’t affect on azulene pharmacokinetics.