| 盐酸普萘洛尔微球剂的制备及其质量评价 |
| |
| 引用本文： | 张奇志,蒋新国,杨程.盐酸普萘洛尔微球剂的制备及其质量评价[J].中国药学杂志,1999,0(5):308-301. |
| |
| 作者姓名： | 张奇志 蒋新国 杨程 |
| |
| 作者单位： | 上海医科大学药学院生物药剂学研究室，上海医科大学药学专业 |
| |
| 摘 要： | 目的:对盐酸普萘洛尔白蛋白微球的制备工艺进行考察,并评价其质量?方法:采用乳化-热固化法制备微球,并对其形态学、载药量、体外释药等性质进行了研究,同时用在体蟾蜍上腭模型评价了其鼻纤毛毒性?结果:微球形态圆整,大小较均匀,粒径1～10μm,载药量4.05%,24h累计释药达85.5%?给予微球4h后,蟾蜍上腭70%纤毛活动剧烈,而溶液剂给药5min,纤毛全部死亡?结论:微球剂的制备工艺对其质量有较大影响,制备良好的微球剂能有效降低盐酸普萘洛尔的鼻纤毛毒性?
|
| 关 键 词： | 盐酸普萘洛尔 白蛋白微球 鼻纤毛毒性 |
| 收稿时间： | 1998-12-10; |
Preparation of BSA propranolol microspheres and its quality evaluation |
| |
| Zhang Qizhi.Preparation of BSA propranolol microspheres and its quality evaluation[J].Chinese Pharmaceutical Journal,1999,0(5):308-301. |
| |
| Authors: | Zhang Qizhi |
| |
| Institution: | (Zhang QZ)，Jiang Xinguo(Jiang XG)，Yang Cheng(Yang C)，et a |
| |
| Abstract: | OBJECTIVE:To study the preparation of BSA-propranolol hydrochloride microspheres (PRO-AM) and evaluate its quality.METHODS:The microspheres were prepared by an emulsion-heat stabilization technique.The morphology of PRO-AM,the drug loading and the release characteristics in vitro were studied.The effects of microspheres on ciliary movement were evaluated in vitro with toad palate model.RESULTS:The microspheres were spherical with size of 1～10μm and drug loading of 4.05%.The drug release was observed up to 85.5% within 24h.While PRO-AM was applied to the upper palate of toad for 4h,more than 70% ciliary moved lively,but all ciliary died 5min after applying PRO solution.CONCLUSION:The preparation of propranolol hydrochloride microspheres seems to decrease the ciliotoxicity of PRO. |
| |
| Keywords: | propranolol hydrochloride albumin microspheres ciliotoxicity |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《中国药学杂志》浏览原始摘要信息 |
| 点击此处可从《中国药学杂志》下载免费的PDF全文 |
|
