吩噻嗪类化合物的合成及其生物活性研究进展

吩噻嗪是含杂原子的三环化合物,于19世纪后半叶在染料工业中发现并被应用。近年来,陆续发现以吩噻嗪结构为母核的部分衍生物具有抗癌、抗菌、抗阿尔兹海默症、抗氧化以及抗病毒等多种药理活性。笔者综述了吩噻嗪类化合物的合成及其相关生物活性研究进展,总结不同活性类型吩噻嗪衍生物的构效关系,为吩噻嗪类化合物的深入系统研究提供参考。

Research Progress in the Synthesis and Biological Activity of Phenothiazines

Phenothiazine is a hetero-atomic tricyclic derivative, which was first discovered and applied in the dye industry in the second half of the 19th century. In recent years, some derivatives with phenothiazine structure as parent nucleus have been found to have a variety of pharmacological activities, such as anti-cancer, antibacterial,anti-Alzheimer, anti-oxidation and anti-virus activities. In order to provide reference for the in-depth systematic research of phenothiazine compounds, this article reviews the research progress in the synthesis of phenothiazine compounds and their related biological activities, and the structure-activity relationship of phenothiazine derivatives with different activity types is summarized.