基于肿瘤微环境增强抗肿瘤治疗效果的纳米递药系统设计及应用

纳米递送系统是当前解决抗肿瘤药物靶向性差、毒副作用大及生物利用度低等关键问题的有效手段之一。与正常组织相比,肿瘤微环境具有一些独特的性质,如血管异常、缺氧和酸性pH等,这些复杂的性质极大的影响药物在肿瘤部位的递送。基于肿瘤微环境来设计纳米递药系统可以改善递送效率以增强抗肿瘤治疗效果。本文综述了肿瘤微环境的组成、特征及基于肿瘤微环境所设计的纳米递药系统的应用研究,并讨论了其中存在的挑战和机遇,旨在为促进纳米递送系统在临床上的实际应用提供参考。

Design and Application of Nano Drug Delivery System for Enhanced Antitumor Therapy Based on Tumor Microenvironment

Nano-delivery system is one of the effective means to solve the key problems of poor targeting, high toxicity and low bioavailability of anti-tumor drugs. Compared with normal tissues, tumor microenvironment has some unique properties, such as abnormal blood vessels, hypoxia and acidic pH, etc. These complex properties greatly affect the delivery of drugs at the tumor site. The design of nano drug delivery system based on tumor microenvironment can improve the delivery efficiency and enhance the anti-tumor therapeutic effect. In this paper, the composition and characteristics of tumor microenvironment and the application of nano-drug delivery system based on tumor microenvironment are summarized, and the challenges and opportunities are discussed, in order to provide reference for promoting the practical application of nano-drug delivery system in clinic.