| 紫杉素磁靶向脂质体的研制及其抗肿瘤作用的研究 |
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| 引用本文： | 张景勍,张志荣,谭群友,陈开杰.紫杉素磁靶向脂质体的研制及其抗肿瘤作用的研究[J].中国药学杂志,2002,22(9):523-525. |
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| 作者姓名： | 张景勍 张志荣 谭群友 陈开杰 |
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| 作者单位： | 1.太极医药研究院，重庆 400015；2.四川大学华西药学院，四川 成都 610044；3. 四川大学华西医学中心96级专题生 |
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| 基金项目： | 重庆市科委基金资助项目（2000-6273） |
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| 摘 要： | 目的：制备紫杉素磁性脂质体，考察有关理化性质、在小鼠体内的分布及其抑瘤作用。方法：用逆相蒸发法制备紫杉素磁性脂质体，对其包封率、粒径和pH值等性质进行了研究，用高效液相色谱法测定了在兔体内的药动学参数，测定了其对小鼠EMT-6肿瘤的抑瘤率。结果：紫杉素磁性脂质体包封率为97.25%,平均粒径为526 nm, pH值为6.20。结论：制备得到的紫杉素磁性脂质体适宜于非胃肠道给药，且具有明显的抑瘤作用。
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| 关 键 词： | 紫杉素 磁性脂质体 |
| 收稿时间： | 2001-11-27; |
Study on preparation of magnetoliposomes-entrapped taxol |
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| ZHANG Jing-Qing,ZHANG Zhi-Rong,TAN Qun-You,et al.Study on preparation of magnetoliposomes-entrapped taxol[J].Chinese Pharmaceutical Journal,2002,22(9):523-525. |
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| Authors: | ZHANG Jing-Qing ZHANG Zhi-Rong TAN Qun-You |
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| Institution: | Academe of Taiji Group Corporation, Chongqing 400015 |
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| Abstract: | OBJECTIVE To study the preparation of paclitaxel entrapped magnetoliposomes (TAX-MLP) and evaluate their quality. METHODS The magnetoliposomes were prepared by reverse-phase evaporation method (REV).The morphology of TAX-MLP, the entrapment efficiency and the pH were studied.RESULTS The mean size of magnetoliposomes was 577 nm and the extent of entrapment of the TAX-MLP was 97.25%.The pH was 6.20.CONCLUSIONS The technology of preparation of paclitaxel magnetoliposomes is practicable and successful. |
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| Keywords: | paclitaxel magnetoliposomes |
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