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香茶菜的免疫药理作用研究
引用本文:陈子珺,李云森,周吉燕,曹露晔,李仪奎.香茶菜的免疫药理作用研究[J].中国药学杂志,2006,41(12):908-909.
作者姓名:陈子珺  李云森  周吉燕  曹露晔  李仪奎
作者单位:1. 上海中医药大学中药研究所,上海,201203
2. 中国科学院上海药物研究所,上海,201203
3. 上海中医药大学科技实验中心,上海,201203
基金项目:国家高技术研究发展计划(863计划)
摘    要: 目的探讨香茶菜的免疫作用。方法采用2,4-二硝基氟苯(DNFB)所致的小鼠迟发型超敏反应模型和绵羊红细胞所致小鼠溶血素抗体生成模型,观察香茶菜水煎剂对整体动物细胞免疫和体液免疫的影响。结果香茶菜水煎剂(10,5,2.5 g·kg-1)对DNFB所致小鼠迟发型超敏反应有显著的抑制作用,对胸腺、脾脏指数无明显影响;对绵羊红细胞所致小鼠特异性抗体生成,香茶菜水煎剂(10,5,2.5 g·kg-1)则有显著的增强作用。结论香茶菜水煎剂能抑制细胞免疫反应,而增强体液免疫反应,具有显著的免疫活性。

关 键 词:香茶菜  迟发型超敏反应  血清溶血素
文章编号:1001-2494(2006)12-0908-03
收稿时间:2005-05-19
修稿时间:2005-05-19

Immunopharmacological Effect of Rabdosia amethystoieds (benth.) Hara in Mice
CHEN Zi-jun,LI Yun-sen,ZHOU Ji-yan,CAO Lu-ye,LI Yi-kui.Immunopharmacological Effect of Rabdosia amethystoieds (benth.) Hara in Mice[J].Chinese Pharmaceutical Journal,2006,41(12):908-909.
Authors:CHEN Zi-jun  LI Yun-sen  ZHOU Ji-yan  CAO Lu-ye  LI Yi-kui
Institution:1.Institute of Chinese Meteria Medica,Shanghai University of Traditional Chinese Medicine, Shanghai 201203,China;2.Shanghai Institute of Materia Medica,Shanghai 201203,China; 3.The Experimental Center of Science and Technology of Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China
Abstract:OBJECTIVE To investigate the immunopharmacological effect of Rabdosia amethystoieds(Benth.) Hara(RAB).METHODS The immunomodulatory effect of RAB was observed by delayed-type hypersensitivity(DTH) induced by DNFB and the production of specific haemolysin antibody against sheep red blood cell(SRBC) in serum.RESULTS RAB decoction markedly inhibited delayed hypersensitivity induced by DNFB in mice,but had no significant effect on the index of thymus and spleen.The level of hemolysin induced by sheeperythrocyte immunization in the serum was increaed.CONCLUSION RAB decoction can markedly inhibit the function of cell-mediate immunity(CMI) and improve the function of humoral immunity in vivo.
Keywords:Rabdosia amethystoieds(Benth  ) Hara  delayed-type hypersensitivity  hemolysin  immunomodulation  
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