青蒿素固体分散物的制备及体外溶出研究

 目的：采用制剂技术方法提高青蒿素的体外溶出速率。方法：采用固体分散技术制备青蒿素固体分散物，对其进行了体外溶出度、平衡溶解度测定，并采用X-射线衍射方法进行固体分散物的物相分析。结果：固体分散物体外溶出速率10min以内达到70％以上，明显比青蒿素原料药的体外溶出速率加快，固体分散物X-射线衍射图谱表明青蒿素以非晶体状态存在；在RH75％40℃条件下放置3个月后，固体分散物X-射线衍射图谱和体外溶出速率均无明显变化。结论：制备青蒿素固体分散体可以提高其体外溶出速率。

Study on prepartion and dissolution of the solid dispersions of artemisinin

OBJECTIVE:The solid dispersion method was used to increase the solubility of artemisinin.METHOD:Solid dispersion of artemisinin was prepared.The solubility and balance dissolution of the solid dispersion was detected.X-Ray powder diffraction was used to investigate the nature of the studied forms.RESULT:The results showed the drug in solid dispersion existed in amorphous form.When the solid dispersion was exposed to an atmosphere of 75% relative humidity for 3 months at 40℃，the solubility and existing state of the solid dispersion did not alter much.The dissolution rates of dispersion was 70% in 10 minutes,which was obviously increased than that of the pure drug,CONCLUSION:The solid dispersion of artemisinin can increase the solubility of artemisinin in virto.